40570-64-7

Basic information

• Product Name: 2-(3-CHLOROPROPIONYL)THIOPHENE
• Synonyms: 2-(3-CHLOROPROPIONYL)THIOPHENE;3-CHLORO-1-(2-THIENYL)-1-PROPANONE;1-Propanone, 3-chloro-1-(2-thienyl)-;3-Chloro-1-(thiophen-2-yl)propan-1-one
• CAS NO: 40570-64-7
• Molecular Formula: C₇H₇ClOS
• Molecular Weight: 174.65
• Mol File: 40570-64-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(3-CHLOROPROPIONYL)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLOROPROPIONYL)THIOPHENE(40570-64-7)
• EPA Substance Registry System: 2-(3-CHLOROPROPIONYL)THIOPHENE(40570-64-7)

Safety Data

• Hazardous Substances Data: 40570-64-7(Hazardous Substances Data)

Usage

General Description

2-(3-chloropropionyl)thiophene is a chemical compound with the molecular formula C8H7ClOS. It is classified as a chlorinated thiophene, and it consists of a thiophene ring with a 3-chloropropionyl group attached to it. 2-(3-CHLOROPROPIONYL)THIOPHENE is used in various industrial applications, including as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as a raw material in the production of dyes, pigments, and coatings. Additionally, 2-(3-chloropropionyl)thiophene is utilized in the manufacturing of polymers and other organic compounds. It is important to handle this chemical with caution, as it is flammable and may pose health hazards if not properly handled and used in controlled conditions.

Upstream product

• 188290-36-0 thiophene 
• 625-36-5 2-chloropropionyl chloride 
• 13191-29-2 thienyl vinyl ketone 

Downstream Products

• 645411-16-1 N-methyl-3-(thien-2-yl)-3-morpholino-propylamine hydrochloride 
• 164071-56-1 (S)-3-chloro-1-(thiophen-2-yl)propan-1-ol 
• 164071-55-0 (R)-3-chloro-1-thiophenyl-2-yl-propan-1-ol 
• 116539-57-2 (R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol 

Relevant articles and documents

Novel 5-hydroxytryptamine and norepinephrine dual reuptake inhibitor and medical application thereof

The invention belongs to the field of medicinal chemistry, particularly relates to a novel serotonin and norepinephrine dual reuptake inhibitor and medical application thereof, and discloses a compound as represented by a formula I and a pharmaceutically acceptable salt thereof, and application of the compound and the pharmaceutically acceptable salt in preparation of antidepressant drugs.

Chemoenzymatic synthesis of (S)-duloxetine using carbonyl reductase from Rhodosporidium toruloides

A chemoenzymatic strategy was developed for (S)-duloxetine production employing carbonyl reductases from newly isolated Rhodosporidium toruloides into the enantiodetermining step. Amongst the ten most permissive enzymes identified, cloned, and overexpressed in Escherichia coli, RtSCR9 exhibited excellent activity and enantioselectivity. Using co-expressed E. coli harboring both RtSCR9 and glucose dehydrogenase, (S)-3-(dimethylamino)-1-(2-thienyl)-1-propanol 3a was fabricated with so far the highest substrate loading (1000 mM) in a space-time yield per gram of biomass (DCW) of 22.9 mmol L-1 h-1 g DCW-1 at a 200-g scale. The subsequent synthetic steps from RtSCR9-catalyzed (S)-3a were further performed, affording (S)-duloxetine with 60.2% overall yield from 2-acethylthiophene in >98.5% ee.

A method for preparing optically active 3-amino-1-propanol derivatives as an intermediate and a method for preparing (S)-duloxetine using the same

The present invention relates to a method for preparing optically active 3-AMNO1-propanol derivatives as an intermediate and a method for preparing (s)-duloxetine using the same. This method can obtain optically active 3-AMNO1-propanol with higher yield and optical purity (ee) than any other conventional methods. Using this as an intermediate compound, it is possible to manufacture duloxetine which is enantiomerically pure and has high optical purity (ee).(DD) Nisoxetine(EE) Duloxetine(CC) 3-amino-1-propanol(BB) Fluoxetine(AA) TomoxetineCOPYRIGHT KIPO 2015