60399-03-3

Basic information

• Product Name: 2-[(propan-2-ylamino)methyl]phenol
• Synonyms: 2-[(propan-2-ylamino)methyl]phenol
• CAS NO: 60399-03-3
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 60399-03-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 49-50 °C
• Boiling Point: 256.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.014±0.06 g/cm3(Predicted)
• PKA: 9.24±0.30(Predicted)
• CAS DataBase Reference: 2-[(propan-2-ylamino)methyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(propan-2-ylamino)methyl]phenol(60399-03-3)
• EPA Substance Registry System: 2-[(propan-2-ylamino)methyl]phenol(60399-03-3)

Safety Data

• Hazardous Substances Data: 60399-03-3(Hazardous Substances Data)

Usage

Classification

Tertiary amine derivative of phenol This indicates that the compound is derived from phenol and contains a tertiary amine group.

Function

Potent and selective antagonist for α1-adrenergic receptors This describes the primary mechanism of action of Ipramidine, as it targets and blocks specific receptors in the body.

Primary use

Nasal decongestant Ipramidine is mainly used to relieve nasal congestion.

Mode of action

Vasoconstriction It works by constricting blood vessels in the nasal passages, which reduces swelling and congestion.

Additional use

Ophthalmic solutions Ipramidine is used in eye drops to reduce redness and swelling of the eye.

Investigated for potential treatment

Conditions like glaucoma, asthma, and urinary incontinence Research has explored the possibility of using Ipramidine for treating various health issues.

Limitations

Cardiovascular side effects and drug interactions These factors restrict the widespread use of Ipramidine as a treatment option.

Upstream product

• 5961-35-3 2-{[(1-methylethyl)imino]methyl}phenol 
• 90-02-8 salicylaldehyde 
• 75-31-0 isopropylamine 

Downstream Products

• 33316-78-8 2-[(isopropyloxy)methyl]phenol 

Relevant articles and documents

Chemoselective Asymmetric Intramolecular Dearomatization of Phenols with α-Diazoacetamides Catalyzed by Silver Phosphate

We report asymmetric dearomatization of phenols using Ag carbenoids from α-diazoacetamides. The Ag catalyst promoted intramolecular dearomatization of phenols, whereas a Rh or Cu catalyst caused C-H insertion and a Büchner reaction. Studies indicated Ag carbenoids have a carbocation-like character, making their behavior and properties unique. Highly enantioselective transformations using Ag carbenoids have not been reported. We achieved a Ag carbenoid-mediated chemo- and highly enantioselective phenol dearomatization with substrate generality for the first time.

PPAR AGONISTS

Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy

A series of 3,4-dihydro-1,3-benzoxazine and 3,4-dihydro-1,3-pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.