604-33-1 Usage
Uses
Cholesteryl linoleate was cosonicated with cholesterol to prepare dispersions were prepared to study the cholesterol to phospholipid ratio in red blood cell membrane. It was used as HPLC standard in the analysis of rat liver lipoproteins.
Definition
ChEBI: The (9Z,12Z)-stereoisomer of cholesteryl octadeca-9,12-dienoate.
Biochem/physiol Actions
Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.
Check Digit Verification of cas no
The CAS Registry Mumber 604-33-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 604-33:
(5*6)+(4*0)+(3*4)+(2*3)+(1*3)=51
51 % 10 = 1
So 604-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C46H78O2/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-26-43(47)48-39-30-33-44(5)38(35-39)29-32-46(7)41-28-27-40(37(4)25-23-24-36(2)3)45(41,6)34-31-42(44)46/h12-13,15-16,29,36-37,39-42H,8-11,14,17-28,30-35H2,1-7H3/b13-12-,16-15-/t37-,39+,40-,41-,42-,44+,45-,46+/m1/s1
604-33-1Relevant articles and documents
Enzymatic synthesis of steryl esters of polyunsaturated fatty acids
Shimada, Yuji,Hirota, Yoshinori,Baba, Takashi,Sugihara, Akio,Moriyama, Shigeru,Tominaga, Yoshio,Terai, Tadamasa
, p. 713 - 716 (1999)
Steryl esters of long-chain fatty acids have water-holding properties, and polyunsaturated fatty acids (PUFA) have various physiological functions. Because steryl ester of PUFA can be expected to have both features, we attempted to synthesize steryl esters of PUFA by enzymatic methods. Among lipases used, Pseudomonas lipase was the most effective for the synthesis of cholesteryl docosahexaenoate. When a mixture of cholesterol/docosahexaenoic acid (3:1, mol/mol), 30% water, and 3000 units/g of lipase was stirred at 40 °C for 24 h, the esterification extent attained 89.5%. Under the same reaction conditions, cholesterol, cholestanol, and sitosterol were also esterified efficiently with docosahexaenoic, eicosapentaenoic, arachidonic, and γ-linolenic acids.
ESTERS OF DCPLA AND METHODS OF TREATMENT USING THE SAME
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Paragraph 0112, (2013/05/23)
The present disclosure relates to esters of 8-[2-(2-pentyl- cyclopropylmethyl)cyclopropyl]-octanoic acid ("DCPLA"). The disclosure further relates to compositions, kits, and methods for treatment using the esters.
