604-33-1

Usage

Uses

Used in Pharmaceutical and Biomedical Research:
Cholesteryl linoleate is used as a research tool for studying the cholesterol to phospholipid ratio in red blood cell membranes. This application helps in understanding the structural and functional aspects of cell membranes, which is crucial for various biomedical and pharmaceutical research.
Used in Analytical Chemistry:
Cholesteryl linoleate serves as a high-performance liquid chromatography (HPLC) standard in the analysis of rat liver lipoproteins. This application is essential for accurate quantification and identification of lipoproteins, which are vital for understanding lipid metabolism and related health conditions.
Used in the Preparation of Dispersions:
Cholesteryl linoleate is used in the co-sonication with cholesterol to prepare dispersions for studying the properties of red blood cell membranes. This application aids in the development of novel drug delivery systems and the investigation of membrane-related phenomena.

Biochem/physiol Actions

Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.

InChI:InChI=1/C46H78O2/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-26-43(47)48-39-30-33-44(5)38(35-39)29-32-46(7)41-28-27-40(37(4)25-23-24-36(2)3)45(41,6)34-31-42(44)46/h12-13,15-16,29,36-37,39-42H,8-11,14,17-28,30-35H2,1-7H3/b13-12-,16-15-/t37-,39+,40-,41-,42-,44+,45-,46+/m1/s1

Upstream product

• 7459-33-8 linoleyl chloride 
• 57-88-5 cholesterol 
• 60-33-3 linoleic acid 
• 57-88-5 cholesterol 

Downstream Products

• 33783-77-6 (9Z,11E)-(S)-13-Hydroxy-octadeca-9,11-dienoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 167354-91-8 cholesteryl 13-hydroxyoctadeca-cis-9,trans-11-dienoate 
• 33783-76-5 cholesteryl 9-hydroxyoctadeca-trans-10,cis-12-dienoate 
• 10219-69-9 (R,S)-coriolic acid 
• 73543-67-6 (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid 
• 82846-48-8 (8E,12Z)-10-hydroxy-8,12-octadecadienoic acid 
• 82854-54-4 (9Z,13E)-12-hydroxy-9,13-octadecadienoic acid 

Relevant academic research and scientific papers

Enzymatic synthesis of steryl esters of polyunsaturated fatty acids

Steryl esters of long-chain fatty acids have water-holding properties, and polyunsaturated fatty acids (PUFA) have various physiological functions. Because steryl ester of PUFA can be expected to have both features, we attempted to synthesize steryl esters of PUFA by enzymatic methods. Among lipases used, Pseudomonas lipase was the most effective for the synthesis of cholesteryl docosahexaenoate. When a mixture of cholesterol/docosahexaenoic acid (3:1, mol/mol), 30% water, and 3000 units/g of lipase was stirred at 40 °C for 24 h, the esterification extent attained 89.5%. Under the same reaction conditions, cholesterol, cholestanol, and sitosterol were also esterified efficiently with docosahexaenoic, eicosapentaenoic, arachidonic, and γ-linolenic acids.

PKC activators and combinations thereof

The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

ESTERS OF DCPLA AND METHODS OF TREATMENT USING THE SAME

The present disclosure relates to esters of 8-[2-(2-pentyl- cyclopropylmethyl)cyclopropyl]-octanoic acid ("DCPLA"). The disclosure further relates to compositions, kits, and methods for treatment using the esters.

PKC ACTIVATORS AND COMBINATIONS THEREOF

The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.