60400-92-2

Usage

Uses

Antiallergic.

InChI:InChI=1/C17H18O5/c1-2-5-11-9-6-3-4-7-10(9)15(19)14-12(18)8-13(17(20)21)22-16(11)14/h8,19H,2-7H2,1H3,(H,20,21)

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 60401-79-8 5-Hydroxy-4-oxo-10-propyl-6,7,8,9-tetrahydro-4H-naphtho [2,3-b]pyran-2-carbonitrile 
• 60401-45-8 ethyl 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho<2,3-b>pyran-2-carboxylate 

Relevant academic research and scientific papers

Compositions and methods for treating certain skin conditions

There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, STR1 in which R1 represents hydrogen, hydroxy or --NR5 R6, in which R5 and R6, which may be the same or different each represents hydrogen or alkyl C 1 to 6, an adjacent pair of R2, R3 and R4 form a --(CH2)4 --chain and the remaining substituent R2 or R4 represents alkyl C 1 to 9, E represents a 5-(1H)tetrazolyl- or a --COOH group, and X represents oxygen or a group --NR7 -- in which R7 may be hydrogen or alkyl C 1 to 6, or a pharmaceutically acceptable derivative thereof, together with a mixture of a solvent for the active ingredient and a non-solvent for the active ingredient, the solvent and the non-solvent being miscible in the relevant proportions and the proportion of the non-solvent being such that the active ingredient forms a solution in the mixture.

Tricyclic mono-chromone-2-carboxylic acids

There are described compounds of formula I, STR1 in which R3 represents hydrogen, or alkyl C 1 to 6, R5 represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, -NR1 R2, halogen, alkyl C 1 to 6, hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6, An adjacent pair of X, Y and Z form a --(CH2)4 --, --CH=CH--CH=CH--or --O(CH2)3 --chain, each of the chains optionally being substituted by one or two C 1 to 6 alkyl groups, and the remaining substituent X or Z represents alkenyl C2 to 6 optionally substituted by phenyl; halogen; or alkyl C 1 to 9 optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy C 1 to 6, Or, when an adjacent pair of X, Y and Z form a chain substituted by one or two C 1 to 6 alkyl groups, the remaining substituent X or Z may be hydrogen, and R1 and R2, which may be the same or different, are each hydrogen or alkyl C 1 to 6, And pharmaceutically acceptable derivatives thereof. Processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds are also described.

Composition for treating skin mast cells and/or delayed cellular hypersensitivity reactions

There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, STR1 in which R1 represents hydrogen, hydroxy or --NR5 R6, in which R5 and R6, which may be the same or different, each represent hydrogen or alkyl C 1 to 6, An adjacent pair of R2, R3 and R4 form a --(CH2)4 -- chain, and the remaining substituent R2 or R4 represents alkyl C 1 to 9, E represents a 5-(IH)tetrazolyl- or a --COOH group, and X represents oxygen or a group --NR7 -- in which R7 may be hydrogen or alkyl C 1 to 6, or a pharmaceutically acceptable derivative thereof. There is also described a method for the treatment of conditions (in man and other animals) which involve skin mast cells and/or delayed (cellular) hypersensitivity reactions, which comprises administering a compound of formula I, or a pharmaceutically acceptable derivative thereof to a subject suffering from such a condition.