60409-96-3Relevant academic research and scientific papers
The Dechlorination of Some Highly Chlorinated Naphthalene Derivatives
Hales, Neil J.,Heaney, Harry,Hollinshead, John H.,Lai, Steven M. F.,Singh, Pritpal
, p. 7777 - 7790 (1995)
The cycloadducts formed between tetrachlorobenzyne and a variety of arenes and cyclic 1,3-dienes have been reductively dechlorinated.The products are formally benzyne cycloadducts, many of which are difficult to make by other routes.High yields are obtained when sodium and t-butanol in boiling THF are used for the reduction.THF serves as a solvent but t-butanol not only acts as a proton donor but also appears to initiate the reduction.Tetrachlorobenzyne should be considered as an alternative reagent whenever benzyne itself appears to be required.
Bridged Ring compounds As Hepatitis C Virus (HCV) Inhibitors And Pharmaceutical Applications Thereof
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, (2015/03/28)
Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.
BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND PHARMACEUTICAL APPLICATIONS THEREOF
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, (2014/02/16)
Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.
Development of two processes for the synthesis of bridged azabicyclic systems: Intermolecular radical addition-homoallylic rearrangements leading to 2-azanorborn-5-enes and neophyl-type radical rearrangements to 2-azabenzonorbornanes
Hodgson, David M.,Bebbington, Magnus W.P.,Willis, Paul
, p. 3787 - 3798 (2007/10/03)
Radical thiol additions to 7-azanorbornadienes give 7-thio-substituted 2-azanorbornenes and Barton deoxygenations of 7-azabenzonorbornanols give 2-azabenzonorbornanes. The processes both involve novel nitrogen-directed radical rearrangements. The kinetics and mechanisms of the reactions are also discussed.
Preparation and Spectroscopic Studies of the 1,4-Dihydro-1,4-iminonaphthalene (7-Azabenzonorbornadiene) Ring System
Davies, John W.,Durrant, Michael L.,Walker, Matthew P.,Belkacemi, Djaballah,Malpass, John R.
, p. 861 - 884 (2007/10/02)
The synthesis of a range of N-alkyl 1,4-dihydro-1,4-iminonaphthalenes (7-azabenzonorbornadienes) and reduced derivatives is described together with 1,4-dihydro-1,4- and 9,10-dihydro-9,10- iminoanthracenes.VT NMR studies lead to unambiguous assignment of i
