55258-00-9

Upstream product

• 26477-20-3 9-methyl-5,6,7,8-tetrachloro-1,4-dihydronaphthalen-1,4-imine 
• 96-54-8 N-Methylpyrrole 
• 462-80-6 benzyne 
• 109-99-9 tetrahydrofuran 
• 1072-85-1 o-fluorobromobenzene 
• 50-00-0 formaldehyd 
• 140118-98-5 1,4-Dihydro-1,4-epiazano-naphthalene; compound with (E)-but-2-enedioic acid 

Downstream Products

• 55257-99-3 N-methyl-1,2,3,4-tetrahydro-1,4-iminonaphthalene 
• 91-20-3 naphthalene 

Relevant academic research and scientific papers

Bridged Ring compounds As Hepatitis C Virus (HCV) Inhibitors And Pharmaceutical Applications Thereof

Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.

BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND PHARMACEUTICAL APPLICATIONS THEREOF

Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.

The Dechlorination of Some Highly Chlorinated Naphthalene Derivatives

The cycloadducts formed between tetrachlorobenzyne and a variety of arenes and cyclic 1,3-dienes have been reductively dechlorinated.The products are formally benzyne cycloadducts, many of which are difficult to make by other routes.High yields are obtained when sodium and t-butanol in boiling THF are used for the reduction.THF serves as a solvent but t-butanol not only acts as a proton donor but also appears to initiate the reduction.Tetrachlorobenzyne should be considered as an alternative reagent whenever benzyne itself appears to be required.

Preparation and Spectroscopic Studies of the 1,4-Dihydro-1,4-iminonaphthalene (7-Azabenzonorbornadiene) Ring System

The synthesis of a range of N-alkyl 1,4-dihydro-1,4-iminonaphthalenes (7-azabenzonorbornadienes) and reduced derivatives is described together with 1,4-dihydro-1,4- and 9,10-dihydro-9,10- iminoanthracenes.VT NMR studies lead to unambiguous assignment of i