6043-42-1Relevant articles and documents
Copper-catalyzed aerobic oxidative C-C bond cleavage of simple ketones for the synthesis of amides
Li, Ke,Liu, Wei,Liu, Yu-Feng,Yang, Guo-Ping,Zeng, Kai
, p. 6958 - 6964 (2020/10/02)
A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon-carbon (C-C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O2 as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.
Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)
Stalder, Henri,Hoener, Marius C.,Norcross, Roger D.
supporting information; experimental part, p. 1227 - 1231 (2011/04/16)
High throughput screening of the Roche compound library identified benzanilides such as 1 and 2 as antagonists of TAAR1. Optimisation of this hit series led to the first selective TAAR1 antagonist (N-(3-Ethoxy-phenyl)-4- pyrrolidin-1-yl-3-trifluoromethyl-
Direct Acylamination of Pyridine 1-Oxide with N-Phenylarenimidoyl Chlorides and Fluorides
Abramovitch, Rudolph A.,Pilski, Jacek,Konitz, Antoni,Tomasik, Piotr
, p. 4391 - 4393 (2007/10/02)
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