6582-42-9

Usage

Uses

Used in Pharmaceutical Industry:
3',4'-DICHLOROPROPIOPHENONE is used as a key intermediate in the synthesis of (S)-3-chloro-1-(4-chlorophenyl)-1-propanol, a compound with potential pharmaceutical applications. Its unique structure and reactivity make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
3',4'-DICHLOROPROPIOPHENONE may also find applications in the agrochemical industry, where it can be used as a precursor for the synthesis of various agrochemicals, such as insecticides, herbicides, and fungicides. Its chlorine-containing structure can contribute to the development of more effective and targeted agrochemical products.

Upstream product

• 79-03-8 propionyl chloride 
• 95-50-1 1,2-dichloro-benzene 
• 53984-12-6 3,4-dichloro-α-ethyl-benzylalcohol 
• 51-44-5 3,4-dichlorbenzoic acid 
• 123-62-6 propionic acid anhydride 
• 6574-99-8 3,4-dichloro-benzonitrile 
• 925-90-6 ethylmagnesium bromide 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Downstream Products

• 715644-76-1 (+/-)-1-Isopropylamino-1-<3.4-dichlor-benzoyl>-aethan 
• 90650-06-9 1-(3,4-dichloro-phenyl)-propan-1-one oxime 
• 620950-21-2 DL-5-ethyl-5-(3',4'-dichlorophenyl)butyrolactone 
• 75847-67-5 2-tert-Butylamino-1-(3,4-dichloro-phenyl)-propan-1-ol 
• 75847-67-5 2-tert-Butylamino-1-(3,4-dichloro-phenyl)-propan-1-ol 
• 191014-78-5 3-Methyl-4-oxo-4-(3',4'-dichlorophenyl)-2-butenoic acid 
• 620950-20-1 C₁₇H₂₂Cl₂O₅ 
• 443144-58-9 3,4-dichloropropiophenone thiosemicarbazone 
• 1312799-17-9 1-(3,4-dichlorophenyl)-1-oxopropan-2-yl benzoate 
• 1394204-83-1 2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(3,4-dichlorophenyl)propan-1-one 
• 6043-42-1 3,4-dichloro-N-phenylbenzamide 
• 103038-79-5 1-(3,4-dichloro-phenyl)-propan-1-one semicarbazone 
• 15861-75-3 1-(3,4-Dichlor-phenyl)-2-oximino-propanon-⁽¹⁾ 

Relevant academic research and scientific papers

Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors

A series of arylalkanol-piperidine derivatives was synthesized, and their triple reuptake inhibition and in vivo activities have been evaluated. Among them, compounds 2a, 2j, 2k, 2m and 2n exhibited high potency for 5-HT, NA and DA transporters. Optimized compounds 2j and 2m showed significant reduction of immobility time compared to that of vehicle in the mouse tail suspension test (TST) test at doses ranging from 10 to 50 mg/kg po, and were not generally motor stimulants at 50 mg/kg dose. In addition, compounds 2j and 2m displayed desirable pharmacokinetic properties in SD rats.

Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: Aids to smoking cessation

To create potentially superior aids to smoking cessation and/or antidepressants and to elucidate bupropions possible mechanisms of action(s), 23 analogues based on its active hydroxymetabolite (2S,3S)-4a were synthesized and tested for their abilities to inhibit monoamine uptake and nAChR subtype activities in vitro and acute effects of nicotine in vivo. The 3′,4′-dichlorophenyl [(±)-4n], naphthyl (4r), and 3-chlorophenyl or 3-propyl analogues 4s and 4t, respectively, had higher inhibitory potency and/or absolute selectivity than (2S,3S)-4a for inhibition of DA, NE, or 5HT uptake. The 3′-fluorophenyl, 3′-bromophenyl, and 4-biphenyl analogues 4c, 4d, and 4l, respectively, had higher potency for antagonism of α4β2-nAChR than (2S,3S)-4a. Several analogues also had higher potency than (2S,3S)-4a as antagonists of nicotine-mediated antinociception in the tail-flick assay. The results suggest that compounds acting via some combination of DA, NE, or 5HT inhibition and/or antagonism of α4β2-nAChR can potentially be new pharmacotherapeutics for treatment of nicotine dependence.

N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide

The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.

Synthesis and evaluation of the anticonvulsant activity of a series of 2-amino-1-phenyl-1-propranols derived from the metabolites of the antidepressant bupropion

A series of 2-amino-1-phenyl-1-propanols that are structurally related to known metabolites of bupropion, 1 (Wellbutrin) were synthesized and evaluated as potential anticonvulsants. The (R*,R*)-2-tert-butylamino-1-(3-trifluoromethylphenyl) propanol 20 had an ED50 of 16.5 ± 2.8 mg/kg ip in mice in the maximal electroshock screen and was chosen for further evaluation.