6582-42-9

Basic information

• Product Name: 3',4'-DICHLOROPROPIOPHENONE
• Synonyms: LABOTEST-BB LT01148402;1-(3,4-DICHLOROPHENYL)-1-PROPANONE;3,4-DICHLOROPHENYL ETHYL KETONE;1-(3,4-Dichlorophenyl)propan-1-one;3'',4''-DICHOROPROPIOPHENONE;1-(3,4-Dichlorophenyl)-1-propanone,99%;3',4'-Dichloropropiophenone
• CAS NO: 6582-42-9
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.07
• EINECS: 229-511-9
• Product Categories: Aromatic Propiophenones (substituted);Adehydes, Acetals & Ketones;Chlorine Compounds;C9;Carbonyl Compounds;Ketones
• Mol File: 6582-42-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 44-46 °C(lit.)
• Boiling Point: 136-140 °C18 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.2568 (rough estimate)
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 3',4'-DICHLOROPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DICHLOROPROPIOPHENONE(6582-42-9)
• EPA Substance Registry System: 3',4'-DICHLOROPROPIOPHENONE(6582-42-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 37/39-26-37
• WGK Germany: 3
• Hazardous Substances Data: 6582-42-9(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO LIGHT YELLOW LOW MELTING SOLID

Uses

3′,4′-Dichloropropiophenone was used in the synthesis of (S)-3-chloro-1-(4-chlorophenyl)-1-propanol.

Upstream product

• 79-03-8 propionyl chloride 
• 95-50-1 1,2-dichloro-benzene 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 123-62-6 propionic acid anhydride 
• 6574-99-8 3,4-dichloro-benzonitrile 
• 925-90-6 ethylmagnesium bromide 
• 51-44-5 3,4-dichlorbenzoic acid 
• 53984-12-6 3,4-dichloro-α-ethyl-benzylalcohol 

Downstream Products

• 25173-68-6 3(3,4-dichlorophenyl)propanoic acid 
• 15861-75-3 1-(3,4-Dichlor-phenyl)-2-oximino-propanon-⁽¹⁾ 
• 75847-67-5 2-tert-Butylamino-1-(3,4-dichloro-phenyl)-propan-1-ol 
• 75847-67-5 2-tert-Butylamino-1-(3,4-dichloro-phenyl)-propan-1-ol 
• 191014-78-5 3-Methyl-4-oxo-4-(3',4'-dichlorophenyl)-2-butenoic acid 
• 765278-99-7 2-phenyl-4-(3,4-dichlorophenyl)-5-methylimidazole 
• 1394204-83-1 2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(3,4-dichlorophenyl)propan-1-one 
• 6043-42-1 3,4-dichloro-N-phenylbenzamide 
• 1088709-04-9 C₂₂H₂₉Cl₂N₅ 
• 132451-07-1 3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine 

Relevant articles and documents

Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors

A series of arylalkanol-piperidine derivatives was synthesized, and their triple reuptake inhibition and in vivo activities have been evaluated. Among them, compounds 2a, 2j, 2k, 2m and 2n exhibited high potency for 5-HT, NA and DA transporters. Optimized compounds 2j and 2m showed significant reduction of immobility time compared to that of vehicle in the mouse tail suspension test (TST) test at doses ranging from 10 to 50 mg/kg po, and were not generally motor stimulants at 50 mg/kg dose. In addition, compounds 2j and 2m displayed desirable pharmacokinetic properties in SD rats.

N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide

The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.