6044-73-1

Usage

Uses

Used in Pharmaceutical Industry:
11-(3-fluorophenyl)-3,3-dimethyl-10-(phenylacetyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one is used as a pharmaceutical compound for its potential therapeutic effects. Its specific application reason is due to its structural similarity to other dibenzodiazepines that have been found to possess various pharmacological properties, such as anti-anxiety, anticonvulsant, and muscle relaxant activities.
Used in Chemical Research:
In the field of chemical research, 11-(3-fluorophenyl)-3,3-dimethyl-10-(phenylacetyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one can be used as a starting material or intermediate for the synthesis of other complex organic molecules. Its unique structure and functional groups make it a valuable candidate for further chemical modifications and exploration of new compounds with potential applications in various industries.
Used in Organic Synthesis:
11-(3-fluorophenyl)-3,3-dimethyl-10-(phenylacetyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one is used as a synthetic intermediate for the production of various organic compounds. Its application reason is based on its structural complexity and the presence of multiple functional groups that can be further modified or reacted with other molecules to create new compounds with specific properties and applications.

Upstream product

• 79-29-8 2,3-dimethylbutane 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 131391-21-4 1,3,4-trimethylarsolene 
• 73411-22-0 1-phenyl-3,4-dimethyl-3-arsolene 

Downstream Products

• 598-31-2 1-bromoacetone 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 20955-40-2 1,4-dibromo-2,3-dimethyl-butane-2,3-diol 
• 138427-92-6 (2RS,3SR)-3,4-epoxy-2,3-dimethyl-1-(phenylthio)butan-2-ol 
• 138427-93-7 (2RS,3RS)-2,3-dimethyl-1,4-bis(phenylthio)butane-2,3-diol 
• 1217550-49-6 (E)-8-(3,4-difluorophenoxy)-2,2,6,7-tetramethyl-4-[1,2,4]triazol-1-yloct-6-en-3-one 
• 54062-61-2 (5E,9E)-12-(3-Methoxy-phenyl)-5,6,9-trimethyl-dodeca-5,9-dien-1-ol 
• 54100-19-5 1-Methoxy-3-((3E,7E)-4,7,8-trimethyl-dodeca-3,7,11-trienyl)-benzene 
• 54062-41-8 4-Methyl-4-((E)-3,4,7-trimethyl-octa-3,7-dienyl)-cyclohex-2-enone 
• 53311-19-6 (5E,9E)-12-(3-Methoxy-phenyl)-5,6,9-trimethyl-dodeca-5,9-dienal 
• 16054-38-9 (E,Z)-1,4-bis(trimethylsilyl)-2,3-dimethyl-2-butene radical cation 

Relevant academic research and scientific papers

One-Pot Synthesis of Metastable 2,5-Dihydrooxepines through Retro-Claisen Rearrangements: Method and Applications

A one-pot methodology to synthesize metastable bicyclic 2,5-dihydrooxepines from cyclic 1,3-diketones and 1,4-dibromo-2-butenes through the retro-Claisen rearrangement of syn-2-vinylcyclopropyl diketone intermediates is reported. DFT calculations were performed to understand the reaction selectivity and mechanisms towards [1,3]- or [3,3]-sigmatropic rearrangements, highlighting the crucial influence of the temperature. The reaction was successfully applied to a short protecting group-free total synthesis of radulanin A, a natural 2,5-dihydrobenzoxepine. Moreover, the strong herbicidal potential of this natural product is demonstrated for the first time.

Total synthesis of celastrol, development of a platform to access celastroid natural products

Celastroid natural products, triterpenes, have been and continue to be investigated in clinical trials. Celastrol, and for that matter any member of the celastroid family, was prepared for the first time through chemical synthesis starting from 2,3-dimethylbutadiene. A triene cyclization precursor generated in 12 steps underwent a nonbiomimetic polyene cyclization mediated by ferric chloride to generate the generic celastroid pentacyclic core. In the cyclization, engagement of a tetrasubstituted olefin formed adjacent all carbon quaternary centers stereospecifically. With access to the carbocyclic core of the family of natural products, wilforic acid and wilforol A were prepared en route to racemic celastrol.

Reaktive Arsen-Heterocyclen. III. 3-Arsolene: Synthese und Reaktionen am Arsen

3-Arsolenes (R=Ph, Me, t-Bu, Cl, R'=H, Me) are readily obtained from zirconocene-butadiene complexes and RAsCl2.Alkylation with methyl iodide gives arsonium salts (R=Ph, Me, t-Bu, R'=H, Me), treatment with sulphur gives sulphides (R=Me, t-Bu), while oxidation with Br2 or SO2Cl2 results in ring cleavage.From chloroarsolene substitution products (R=I, H, SPh, OMe, NMe2) as well as coupling products with As-As, As-O-As, and As-S-As units were synthesized.In addition, a number of arsolene complexes with the metals chromium, molybdenum, tungsten, and ruthenium is described. Key words: Arsolene; Zirconocene; Group 6; Ruthenium; Phosphorus

The Reaction of 1,2:3,4-Diepoxy-2,3-dimethylbutane with Nucleophiles

To find out whether the 1,4-addition to 1,2:3,4-diepoxides, which so far has been observed only once, is of a more general character, we investigated the reaction of a variety of O-, C-, N-, and S-nucleophiles with the model compound 1,2:3,4-diepoxy-2,3-dimethylbutane (Scheme 4).In several cases, 1,4-addition products could, indeed, be observed besides the expected 1,2-adducts (Table).

SYNTHESIS OF (Z)- AND (E)-3,4-DIMETHYL-HEX-3-ENE-1,6-DIOLS

(Z)- and (E)-3,4-dimethyl-hex-3-ene-1,6-diols (1 and 2) have been synthesized in 23percent and 68percent yields by a three step sequence requiring only one purification at the end.The steps are a) coupling of 2-lithio-1,3-dithiane with (Z)- or (E)-1,4-dibromo-2,3-dimethylbut-2-ene (3 or 4), b) hydrolysis of the thioketals (8 and 9) with methyl iodide in a mixture of acetonitrile, acetone and water to give the 3,4-dimethyl-hex-3-ene-1,6-diols (10 and 11) and c) reduction with diisobutylaluminum hydride to provide the (Z)- and (E)-diols.

Ozonolysis of Some Tetrasubstituted Ethylenes

The olefins 1,4-dibromo-2,3-dimethyl-2-butene, 1-bromo-2,3-dimethyl-2-butene, and 2,3-dimethyl-2-butene were ozonized under a variety of conditions.Ozonolysis of 1,4-dibromo-2,3-dimethyl-2-butene in acetone solvent leads to the unexpected products acetone diperoxide and triperoxide.The results are discussed with respect to questions of concertedness in ozonide formation, the need for activating groups in ozonide formation, and the possible intermediacy of dioxiranes.