60442-34-4 Usage
Uses
Used in Pharmaceutical Applications:
2-(2-CHLORO-ACETYLAMINO)-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER is used as a precursor in the synthesis of various compounds for drug development, particularly in the production of antimicrobial and antifungal agents. Its unique structure allows it to be a versatile building block in the creation of more complex molecules with therapeutic properties.
Used in Scientific Research:
In the scientific community, 2-(2-CHLORO-ACETYLAMINO)-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER is utilized in organic synthesis for the development of new chemical entities. Its reactivity and structural features make it a valuable component in the exploration of novel chemical reactions and the synthesis of bioactive molecules.
Used in Organic Synthesis:
2-(2-CHLORO-ACETYLAMINO)-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER is employed as a building block in organic synthesis, where it contributes to the formation of more complex molecules with potential applications in various fields, including medicine, materials science, and agrochemicals. Its presence in these molecules can influence their properties and reactivity, making it an important component in the design and synthesis of new compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 60442-34-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,4,4 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 60442-34:
(7*6)+(6*0)+(5*4)+(4*4)+(3*2)+(2*3)+(1*4)=94
94 % 10 = 4
So 60442-34-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H14ClNO3S/c1-4-16-11(15)9-6(2)7(3)17-10(9)13-8(14)5-12/h4-5H2,1-3H3,(H,13,14)
60442-34-4Relevant academic research and scientific papers
Substituted chloroacetamides as potential cancer stem cell inhibitors: Synthesis and biological evaluation
Athavale, Maithili,Kharkar, Prashant S.,Padhariya, Komal N.,Srivastava, Sangeeta
, (2019/12/15)
Cancer kills, irrespective of geographical and cultural origin. Novel modalities for treating cancer are desperately needed. Cancer stem cells (CSCs), main culprits behind chemoresistance and tumor relapse, are one of the few logical choices. Herein, we r
New syntheses of 2-alkylthio-4-oxo-3,4-dihydroquinazolines, 2-alkylthioquinazolines, as well as their hetero analogues
Gruner, Margit,Rehwald, Matthias,Eckert, Katrin,Gewald, Karl
, p. 2363 - 2377 (2007/10/03)
N-Chloroacetylanthranilic acid ethyl ester reacts with potassium thiocyanate in the presence of alcohol to give the (4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)acetic acid ester (3a). In the presence of water or amines the acetic acid derivative (3b) or the acetamide derivatives (3c,d) are obtained. 2-Amino-4-oxo-3,4-dihydroquinazolines (4) arise if vigorous reaction conditions are employed. Analogously, N-chloroacetyl derivatives of 5-membered heterocycles with enaminocarbonyl structure (5, 7, 9, 11, 13, 20, 23) react with potassium thiocyanate to yield thieno[2,3-d]-, thieno[3,2-d]-, imidazo[4,5-d]-, pyrrolo[3,2-d]-, and thiazolo[4,5-d]pyrimidines (6, 8, 10, 12, 14, 21, 24). Quinazolines (18, 19) are formed from the reaction of 2-chloroacetylaminoacetophenone (16a) and 2-chloroacetylaminobenzophenone (16b) with potassium thiocyanate and subsequent treatment of the intermediates with amines.
