60442-58-2Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study
Elmenier, Fatma M.,Lasheen, Deena S.,Abouzid, Khaled A. M.
, p. 315 - 332 (2022/01/04)
Cancer is one of the most aggressive diseases characterised by abnormal growth and uncontrolled cell division. PI3K is a lipid kinase involved in cancer progression which makes it fruitful target for cancer control. 28 new morpholine based thieno[2,3-d] p
ZnO-CeO2 nanocomposite: Efficient catalyst for the preparation of thieno[2,3-d]pyrimidin-4(3H)-one derivatives
Ghayour, Farzaneh,Mohammad Shafiee, Mohammad Reza,Ghashang, Majid
, p. 21 - 26 (2018/04/30)
The Zinc oxide-cerium oxide (ZnO-CeO2) nanocomposite was prepared by a coprecipitation method and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and particle size distribution analysis. The XRD p
Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe
Amawi, Haneen,Karthikeyan, Chandrabose,Pathak, Rekha,Hussein, Noor,Christman, Ryann,Robey, Robert,Ashby, Charles R.,Trivedi, Piyush,Malhotra, Ashim,Tiwari, Amit K.
, p. 1053 - 1065 (2017/08/02)
In this study, a series of 13 structural variants of thieno[2,3d]pyrimidine derivatives (6a-6m) were synthesized and screened for cytotoxicity in a panel of colorectal, ovarian, and brain cancer cell lines. The selectivity of the compounds was assessed by
Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one- based analogs
Wang, Yanong D.,Johnson, Steven,Powell, Dennis,McGinnis, John P.,Miranda, Miriam,Rabindran, Sridhar K.
, p. 3763 - 3766 (2007/10/03)
On the basis of a screening lead from an assay using a pair of p21 isogenic cell lines (p21-proficient cells and p21-deficient cells) to identify chemoselective agents, a series of novel thieno[2,3-d]pyrimidin-4(1H)-one-based analogs was prepared. Some an
Reaction of Nitriles under Acidic Conditions. Part I. A General Method of Synthesis of Condensed Pyrimidines
Dave, K. G.,Shishoo, G. J.,Devani, M. B.,Kalyanaraman, R.,Ananthan, S.,et. al.
, p. 1497 - 1500 (2007/10/02)
Nitriles are known to give rise to salts of different compositions with halogen acids.Many of the reactions undergone by nitriles under the influence of halogen acids are, in many cases, assumed to proceed via the intermediate formation of highly reactive
