60460-71-1

Basic information

• Product Name: 2-methyl-6-(N-morpholinyl)methylphenol
• Synonyms: 2-methyl-6-(N-morpholinyl)methylphenol
• CAS NO: 60460-71-1
• Molecular Weight: 207.272
• Mol File: 60460-71-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-methyl-6-(N-morpholinyl)methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-6-(N-morpholinyl)methylphenol(60460-71-1)
• EPA Substance Registry System: 2-methyl-6-(N-morpholinyl)methylphenol(60460-71-1)

Safety Data

• Hazardous Substances Data: 60460-71-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 95-48-7 ortho-cresol 
• 75-09-2 dichloromethane 
• 16419-60-6 2-Methylphenylboronic acid 

Relevant articles and documents

The modified-Mannich reaction: Conversion of arylboronic acids and subsequent coupling with paraformaldehyde and amines toward the one-pot synthesis of Mannich bases and benzoxazines

A modified Mannich reaction has been developed for the synthesis of Mannich bases and benzoxazines via the oxidative hydroxylation of arylboronic acids and subsequent coupling with paraformaldehyde and amines in one pot. This modified Mannich reaction is easily carried out to afford the target products in good to excellent yields and tolerates a variety of functional groups.

Regioselective mannich reaction of phenols under high pressure using dichloromethane as C1 unit

Regioselectivity in Mannich reaction of 4-, 3-, and 2-substituted phenols with typical heterocyclic amines are investigated under reaction conditions developed by us. Phenol and 4-alkyl, and 4-chlorophenols in the title reaction predominantly gave the corresponding 2-(aminomethyl)phenols, while 4-methoxyphenol afforded, in addition to the mono(aminomethyl)phenols, a considerable amount of the bis adducts. Peculiarly enough, 3-methylphenol with amines afforded 3-methyl-4-(aminomethyl)phenols whereas 2-methylphenol produced 2-methyl-6-(aminomethyl)phenols.