60468-36-2

Basic information

• Product Name: 2-CHLORO-2',5'-DIFLUOROACETOPHENONE
• Synonyms: 2-CHLORO-2',5'-DIFLUOROACETOPHENONE;2-CHLORO-2,5-DIFLUOROACETOPHENONE;2,5-difluorophenacyl chloride;2-chloro-1-(2,5-difluorophenyl)ethanone;2,5-difluorophenacyl chloride ,2-chloro-1-(2,5-difluorophenyl)ethanone;2-Chloro-1-(2,5-difluorophenyl)ethanone[2-Chloro-2',5'-difluoroacetophenone]
• CAS NO: 60468-36-2
• Molecular Formula: C₈H₅ClF₂O
• Molecular Weight: 190.57
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Benzene series;Acetophenone series;Fluorine series
• Mol File: 60468-36-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 49-50 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 240.5 °C at 760 mmHg
• Flash Point: 99.3 °C
• Appearance: White solid
• Density: 1.353 g/cm³
• Vapor Pressure: 0.00441mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-CHLORO-2',5'-DIFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-2',5'-DIFLUOROACETOPHENONE(60468-36-2)
• EPA Substance Registry System: 2-CHLORO-2',5'-DIFLUOROACETOPHENONE(60468-36-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 60468-36-2(Hazardous Substances Data)

Usage

Uses

2-Chloro-2'',5''-difluoroacetophenone

InChI:InChI=1/C8H5ClFNO2/c9-7-2-1-3-8(10)6(7)4-5-11(12)13/h1-5H/b5-4-

Upstream product

• 1979-36-8 2',5'-difluoroacetophenone 
• 540-36-3 para-difluorobenzene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 944472-99-5 (4S)-5,5-diphenyl-4-isopropyl-3-[(2R,3R)-4-chloro-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-1-oxobutyl]-1,3-oxazolidin-2-one 
• 944473-05-6 (2R,3R)-3-[3-(2,5-difluorophenyl)-3,4-epoxy-2-methyl]butanoic acid 
• 59630-49-8 2,5-difluoroisoproterenol 
• 59630-51-2 2,5-difluoro-α-[[[1,1-dimethylethyl]amino]methyl]-benzenemethanol 
• 241479-67-4 Isavuconazole 
• 1157938-97-0 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone 
• 241479-74-3 (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile 

Relevant articles and documents

Cascade Trisulfur Radical Anion (S3?-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles

Trisulfur radical anion (S3?-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the construction of 1,2,3-thiadiazoles and isothiazoles has been developed. S3?- is in situ generated from potassium sulfide in DMF. These two approaches provide a new, safe, and simple way to construct 4-subsituted 1,2,3-thiadiazoles, 5-subsituted 1,2,3-thiadiazoles, and isothiazole in good yields. The reactions include the formation of the new C-S and N-S bonds via S3?- addition and electron detosylation under mild conditions.

PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN

Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of the active pharmaceutical ingredient named Omarigliptin.

Asymmetric zinc-Reformatsky reaction of Evans chiral imide with acetophenones and its application to the stereoselective synthesis of triazole antifungal agents

The Ni(acac)2 catalytic ZnEt2-mediated asymmetric Reformatsky-type reaction of Evans chiral imide with various acetophenones was studied. The chiral imido zinc enolate, which was formed through the metal-halogen exchange reaction of