60468-54-4

Usage

Uses

Used in Military and Law Enforcement:
2-Methyl-3-nitrobenzyl chloride is used as a lachrymatory agent for crowd control and area denial purposes. Its irritating properties make it effective in dispersing crowds and creating a temporary barrier in certain situations.
Used in Chemical Research:
In the field of chemical research, 2-Methyl-3-nitrobenzyl chloride serves as a valuable compound for studying the effects of various chemical modifications on its properties and reactivity. This can lead to the development of new compounds with specific applications in various industries.
Used in Pharmaceutical Industry:
2-Methyl-3-nitrobenzyl chloride is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Pest Control:
Due to its lachrymatory properties, 2-Methyl-3-nitrobenzyl chloride can be used in the development of pest control products. Its ability to cause discomfort to pests can make it a useful component in formulations designed to repel or deter unwanted creatures.
Used in Industrial Applications:
In certain industrial processes, 2-Methyl-3-nitrobenzyl chloride may be utilized as a chemical intermediate for the production of various chemicals and materials. Its unique properties can contribute to the development of new products with specific applications in the industry.

InChI:InChI=1/C8H8ClNO2/c1-6-7(5-9)3-2-4-8(6)10(11)12/h2-4H,5H2,1H3

Upstream product

• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 39053-41-3 2-methyl-3-nitrobenzoyl chloride 
• 83-41-0 2,3-dimethylnitrobenzene 

Downstream Products

• 23876-15-5 2-(3-nitro-2-methylphenyl)acetic acid 
• 101566-00-1 2-methyl-3-nitrophenylethanoyl chloride 
• 91374-23-1 1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene 
• 91374-21-9 Ropinirole 
• 91374-22-0 2-(2-methyl-3-nitro-phenyl)-N,N-di-n-propylacetamide 
• 97351-95-6 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>pyruvic acid 
• 91374-25-3 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride 
• 1103458-49-6 2-(3-nitro-2-methylbenzyl)-4,5-dichloropyridazin-3-one 
• 23876-14-4 3-nitro-2-methylphenylacetonitrile 
• 219312-27-3 3-amino-2-methylphenylacetonitrile 
• 1439397-57-5 C₂₇H₂₆N₈O₂S 
• 946130-08-1 2-(2-methyl-3-nitrobenzyl)-3-oxobutanoic acid ethyl ester 
• 1153081-32-3 (2-methyl-3-nitrobenzyl)hydrazine 
• 6551-36-6 4-(2-methyl-3-nitro-benzyl)-morpholine 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE

Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): [wherein X represents a chlorine atom, a bromine atom, or an iodine atom] with halogen in the presence of a heterogeneous transition metal catalyst to produce 2-(halogenomethyl)-1-methyl-3-nitrobenzene represented by formula (1): [wherein the symbol is as defined above].

Synthesis of 4-N,N-dialkylaminoethyl-2-indolones as potential dopamine agonists

A set of fourteen 4-ethyl>-2-indolone analogues of dopamine were synthesized in 15 steps and evaluated for their affinities towards the D2 receptor using sulpiride or spiperone as radioligands.Six analogues displayed D2 agonist activities comparable (Ki = 450 - 650 nM) to Ropinirole or SK and F 101468.The functionalized amino side chain introduced in the 4-position can be used to modulate the lipophlicity of the analogues without significantly affecting D2 activity. - Keywords: lactam; indolone; rigid dopamine analogue; D2 receptor binding

4--2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist

4--2(3H)-indolone (1c) (SK and F 101468) is a potent and selective prejunctional dopamine receptor agonist.It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM).Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats.It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.