60468-54-4

Basic information

• Product Name: 2-Methyl-3-nitrobenzyl chloride
• Synonyms: BENZENE, 1-(CHLOROMETHYL)-2-METHYL-3-NITRO-;2-(CHLOROMETHYL)-6-NITROTOLUENE;2-METHYL-3-NITROBENZYL CHLORIDE;alpha-chloro-2-methyl-3-nitrotoluene;Benzene, 1-(chloromethyl)-2-methyl-3-nitro- (9CI);a1-Chloro-3-nitro-o-xylene;a-Chloro-2-methyl-3-nitrotoluene;1-(Chloromethyl)-2-methyl-3-nitrobenzene
• CAS NO: 60468-54-4
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• EINECS: 262-249-3
• Product Categories: HALOMETYL;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 60468-54-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 43-46 °C(lit.)
• Boiling Point: 299.7 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: yellow-brown chunks
• Density: 1.2797 (rough estimate)
• Vapor Pressure: 0.00208mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Toluene
• CAS DataBase Reference: 2-Methyl-3-nitrobenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-nitrobenzyl chloride(60468-54-4)
• EPA Substance Registry System: 2-Methyl-3-nitrobenzyl chloride(60468-54-4)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 60468-54-4(Hazardous Substances Data)

Usage

Chemical Properties

yellow-brown chunks

General Description

2-Methyl-3-nitrobenzyl chloride is a lachrymatory agent.

InChI:InChI=1/C8H8ClNO2/c1-6-7(5-9)3-2-4-8(6)10(11)12/h2-4H,5H2,1H3

Upstream product

• 83-41-0 2,3-dimethylnitrobenzene 
• 39053-41-3 2-methyl-3-nitrobenzoyl chloride 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 

Downstream Products

• 617709-45-2 1-(2-Methyl-3-nitrobenzyl)piperidine 
• 23876-14-4 3-nitro-2-methylphenylacetonitrile 
• 1089278-99-8 1-methyl-4-[(2-methyl-3-nitrophenyl)methyl]piperazine 
• 1153081-32-3 (2-methyl-3-nitrobenzyl)hydrazine 
• 946130-08-1 2-(2-methyl-3-nitrobenzyl)-3-oxobutanoic acid ethyl ester 
• 1439397-57-5 C₂₇H₂₆N₈O₂S 
• 219312-27-3 3-amino-2-methylphenylacetonitrile 
• 6551-36-6 4-(2-methyl-3-nitro-benzyl)-morpholine 
• 1103458-49-6 2-(3-nitro-2-methylbenzyl)-4,5-dichloropyridazin-3-one 
• 180080-59-5 N-(2-methyl-3-nitrophenylmethyl)iminodicarboxylic acid di-t-butyl ester 
• 91374-25-3 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride 
• 97351-95-6 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>pyruvic acid 
• 91374-22-0 2-(2-methyl-3-nitro-phenyl)-N,N-di-n-propylacetamide 
• 91374-21-9 Ropinirole 

Relevant articles and documents

METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE

Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): [wherein X represents a chlorine atom, a bromine atom, or an iodine atom] with halogen in the presence of a heterogeneous transition metal catalyst to produce 2-(halogenomethyl)-1-methyl-3-nitrobenzene represented by formula (1): [wherein the symbol is as defined above].

4--2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist

4--2(3H)-indolone (1c) (SK and F 101468) is a potent and selective prejunctional dopamine receptor agonist.It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM).Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats.It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.