604759-84-4Relevant academic research and scientific papers
Gram-scale ketone synthesis by direct reductive coupling of alkyl iodides with acid chlorides
Lu, Wenbin,Liang, Zhuye,Zhang, Yuwei,Wu, Fan,Qian, Qun,Gong, Hegui
, p. 2234 - 2240 (2013/09/02)
Alkyl aryl ketones were prepared on a gram scale by the nickel-catalyzed reductive coupling of alkyl iodides with aroyl chlorides. When scaled up 30-fold, this reaction shows a comparable coupling efficiency to the previously reported reaction performed under small-scale conditions. The mild and convenient reaction conditions show excellent tolerance to a range of functional groups and provide the ketones in good to excellent yields. Georg Thieme Verlag Stuttgart. New York.
Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides
Yin, Hongyu,Zhao, Chenglong,You, Hengzhi,Lin, Kunhua,Gong, Hegui
supporting information; experimental part, p. 7034 - 7036 (2012/08/14)
Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc2O and MgCl2. The Royal Society of Chemistry 2012.
Ketone formation via mild Nickel-catalyzed reductive coupling of alkyl halides with aryl acid chlorides
Wu, Fan,Lu, Wenbin,Qian, Qun,Ren, Qinghua,Gong, Hegui
supporting information; experimental part, p. 3044 - 3047 (2012/08/07)
The present work highlights unprecedented Ni-catalyzed reductive coupling of unactivated alkyl iodides with aryl acid chlorides to efficiently generate alkyl aryl ketones under mild conditions.
