604767-06-8

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 604766-97-4 (2S)-2-(2-methoxymethylpyrrolidin-1-yl)phthalimide 
• 85-44-9 phthalic anhydride 
• 604767-00-2 3-hydroxy-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one 

Relevant academic research and scientific papers

A conceptually new approach to the asymmetric synthesis of 3-aryl and alkyl poly-substituted isoindolinones

A conceptually new and efficient asymmetric synthesis of C-3 arylated or alkylated poly-substituted isoindolinones is reported. The key step is the diastereoselective reduction of an N-acylhydrazonium species derived from the previously assembled corresponding hydroxyl derivative bearing the (S)-2-methoxymethylpyrrolidine (SMP) auxiliary.

A new synthetic route to highly enantioenriched 3-substituted-2,3-dihydro-1H-isoindol-1-ones

A concise and efficient synthesis of highly enantioenriched 3-alkyl and 3-aryl-2,3-dihydro-1H-isoindolinones is reported. The key step relies on the diastereoselective reduction of the N-acylhydrazonium salts generated by acidic treatment of hemiaminal precursors bearing the (S)-2-methoxymethylpyrrolidin-1-yl (SMP) auxiliary.