604766-97-4

Upstream product

• 85-44-9 phthalic anhydride 
• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 

Downstream Products

• 604767-00-2 3-hydroxy-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 604767-02-4 3-Hydroxy-2-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3-(2-methoxy-phenyl)-2,3-dihydro-isoindol-1-one 
• 604767-09-1 (2S,3R)-2-(2-methoxymethylpyrrolidin-1-yl)-3-(3-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one 
• 604767-08-0 (2S,3S)-2-(2-methoxymethylpyrrolidin-1-yl)-3-(2-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one 
• 604767-06-8 (3R)-2-[(2S)-2-methoxymethyl-pyrrolidine-1-yl]-3-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 131615-22-0 (3R)-3-Methyl-2,3-dihydro-1H-isoindol-1-one 
• 604767-03-5 3-Hydroxy-2-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3-(3-methoxy-phenyl)-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

A new synthetic route to highly enantioenriched 3-substituted-2,3-dihydro-1H-isoindol-1-ones

A concise and efficient synthesis of highly enantioenriched 3-alkyl and 3-aryl-2,3-dihydro-1H-isoindolinones is reported. The key step relies on the diastereoselective reduction of the N-acylhydrazonium salts generated by acidic treatment of hemiaminal precursors bearing the (S)-2-methoxymethylpyrrolidin-1-yl (SMP) auxiliary.