604767-08-0

Upstream product

• 85-44-9 phthalic anhydride 
• 604766-97-4 (2S)-2-(2-methoxymethylpyrrolidin-1-yl)phthalimide 
• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 604767-02-4 3-Hydroxy-2-((S)-2-methoxymethyl-pyrrolidin-1-yl)-3-(2-methoxy-phenyl)-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

A new synthetic route to highly enantioenriched 3-substituted-2,3-dihydro-1H-isoindol-1-ones

A concise and efficient synthesis of highly enantioenriched 3-alkyl and 3-aryl-2,3-dihydro-1H-isoindolinones is reported. The key step relies on the diastereoselective reduction of the N-acylhydrazonium salts generated by acidic treatment of hemiaminal precursors bearing the (S)-2-methoxymethylpyrrolidin-1-yl (SMP) auxiliary.