6048-14-2

Upstream product

• 22422-16-8 (E)-1-bromo-4-phenylbut-3-en-2-one 
• 603-35-0 triphenylphosphine 
• 22422-16-8 α-bromomethyl styryl cetone 
• 122-57-6 1-Phenylbut-1-en-3-one 

Downstream Products

• 923025-67-6 (5Z)-3,4-dimethyl-5-[(E)-2-oxo-4-phenylbut-3-enylidene]furan-2(5H)-one 
• 923025-74-5 2-(1-hydroxy-3-phenyl-allylidene)-4,5-dimethyl-cyclopent-4-ene-1,3-dione 
• 923025-68-7 (5E)-5-[(E)-2-oxo-4-phenylbut-3-enylidene]-3-phenylfuran-2(5H)-one 
• 923025-66-5 (5E)-3-methyl-5-[(E)-2-oxo-4-phenylbut-3-enylidene]furan-2(5H)-one 
• 60299-77-6 cinnamoyl cyanide 
• 98749-52-1 4-phenyl-1-(triphenylphosphoranylidene)-(3E)-buten-2-one 

Relevant academic research and scientific papers

Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues

Coruscanone A, a plant-derived cyclopentenedione derivative, showed potent in vitro antifungal activity against Candida albicans and Cryptococcus neoformans comparable to amphotericin B and fluconazole. A series of analogues have been synthesized by modification of the cyclopentenedione ring, the enolic methoxy functionality, and the side chain styryl moiety of this natural product lead. A structurally close 1,4-benzoquinone analogue was also prepared. All the compounds were examined for their in vitro activity against major opportunistic fungal pathogens including C. albicans, C. neoformans, and Aspergillus fumigatus and fluconazole-resistant C. albicans strains, with several analogues demonstrating potent antifungal activity. Structure-activity relationship studies indicate that the 2-methoxymethylenecyclopent-4-ene-1,3-dione structural moiety is the pharmacophore responsible for the antifungal activity of this class of compounds while the side chain styryl-like moiety plays an important complementary role, presumably contributing to target binding.

Novel cyclopentenedione antifungal compounds and methods for their use

Compounds and methods useful in the control, treatment, and prevention of fungal activity, of the following formula: where R1-3 are independently H, alkyl, methyl, acyl, halogen, phenyl, R4 is H, alkyl, methyl, acyl, alkoxy, halogen,

Antifungal cyclopentenediones from Piper coruscans

Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida a