60299-77-6Relevant academic research and scientific papers
Spontaneous Dimerization of Allenes in Situ: An Efficient Synthesis of Substituted 1,2-Dimethylenecyclobutanes with High Regio- and Stereoselectivities
Miao, Maozhong,Wang, Wenmin,Yang, Weijun,Xu, Lijun,Ma, Jing,Ren, Hongjun
, p. 14447 - 14453 (2015)
An intermolecular [2+2] cycloaddition reaction for the synthesis of 1,2-dimethylenecyclobutane derivatives from the commercially available starting materials aryl acetylenes, nBuLi, formamides, and trimethylsilyl cyanide (TMSCN) has been achieved. This reaction displays high regio- and stereoselectivities due to the captodative effect. The mechanism of the reaction has been investigated by the deuterium labeling experiments and DFT calculations. Cycloaddition of captodative allenes: A regio- and stereoselective intermolecular [2+2] cycloaddition of captodative allenes (in situ generated) for the efficient synthesis of substituted 1,2-dimethylenecyclobutanes is disclosed (see scheme; TMS = trimethylsilyl). The mechanism of the reaction has been investigated by deuterium labeling experiments and the selectivity has been studied by DFT calculations.
Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction
Chen, Zhengwang,Wen, Xiaowei,Zheng, Weiping,He, Ruolan,Chen, Dou,Cao, Dingsheng,Long, Lipeng,Ye, Min
supporting information, p. 5691 - 5701 (2020/04/10)
Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcohols have been developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides or esters in moderate to excellent yields. This approach features a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity, and the potential for further transformation of the cyano group.
Bacterial cell leakage potential of newly synthesized quinazoline derivatives of 1,5-benzodiazepines analogue
Dwivedi, Jaya,Kishore, Dharma,Misra, Apoorva,Sharma, Swapnil,Shukla, Shruti
, (2020/02/13)
Novel quinazoline embellished analogues of 1,5-benzodiazepine (6, 9, 13, 17, 21 and 24) were synthesized using one-pot domino approach. Structure of the compounds synthesized, were established with the help of IR, 1H NMR, 13C NMR and
A process for preparing β - cyano compound styrene-isobutene method (by machine translation)
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Paragraph 0023; 0025; 0027; 0028; 0029; 0031; 0033, (2017/07/22)
The invention discloses a on the isobutene β - cyano styrene synthetic method of the compound. The method utilizes a cinnamic acid compounds and azo azobisisobutyronitrile as reaction raw material, the ferric iron catalytic, in the acetonitrile solution in heating by the reaction to the isobutene escapes suosuo the coupling β - cyano styrenic compound. The preparation method of the raw material, cheap and easily obtained catalyst, mild reaction system, the operation is simple, non-ligand, alkali, such as participation of the oxidizing agent. At the same time, use of non-toxic azo azobisisobutyronitrile as a cyano source, has outstanding safety, green and environmental protection. (by machine translation)
βUnsaturated acyl cyanides as new bis-electrophiles for enantioselective organocatalyzed formal [3+3]spiroannulation
Goudedranche, Sebastien,Bugaut, Xavier,Constantieux, Thierry,Bonne, Damien,Rodriguez, Jean
supporting information, p. 410 - 415 (2014/04/03)
α,β-Unsaturated acyl cyanides are key bis-electrophile substrates for successful domino enantioselective organocatalyzed Michael-intramolecular acylation domino sequences. This new reactivity has been applied to the synthesis of enantioenriched azaspiro[4
ETHYLENIC ACYL CYANIDES II: CONJUGATE ADDITION OF ALKYNYLSILANES TO ETHYLENIC ACYL CYANIDES.
Jellal, Abdelkebir,Zahra, Jean-Pierre,Santelli, Maurice
, p. 1395 - 1398 (2007/10/02)
3-Alkynylacyl cyanides or 3-alkynylacids and their esters can be obtained by a conjugate addition of alkynylsilanes to α,β-ethylenic acyl cyanides.
Synthesis of α,β-Unsaturated and Other Reactive Acyl Cyanides
Hoffmann, H. M. R.,Haase, Klaus,Ismail, Zeinhom M.,Preftitsi, Stamatia,Weber, Anette
, p. 3880 - 3885 (2007/10/02)
Reaktive aliphatische Acylcyanide (1 - 10, siehe Tab. 1) werden aus Acylchloriden, Natriumiodid und Kupfer(I)-cyanid unter verschiedenen Bedingungen dargestellt.Die Reaktion verlaeuft ueber die Acyliodide.
TRIBUTYLTIN CYANIDE: A FACILE CYANATING AGENT OF ACYL CHLORIDES
Tanaka, Masato
, p. 2959 - 2962 (2007/10/02)
Tributyltin cyanide was prepared from tributyltin chloride and potassium cyanide, and was found to be an efficient cyanation reagent for acyl chlorides to give acyl cyanides in excellent yields.
