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60480-69-5

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60480-69-5 Usage

General Description

3-Acetamido-1,2,3,4-tetrahydrocarbazole is a chemical compound with the molecular formula C15H16N2O. It is a derivative of carbazole, a tricyclic aromatic hydrocarbon, and contains an acetamido group. 3-acetaMido-1,2,3,4-tetrahydrocarbazole is often used as a precursor in the synthesis of various pharmaceuticals and organic compounds. It is also known for its potential biological activities, including anti-tumor and anti-inflammatory properties. 3-Acetamido-1,2,3,4-tetrahydrocarbazole may have potential applications in medicinal chemistry and drug development due to its unique structure and potential therapeutic effects.

Check Digit Verification of cas no

The CAS Registry Mumber 60480-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,4,8 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 60480-69:
(7*6)+(6*0)+(5*4)+(4*8)+(3*0)+(2*6)+(1*9)=115
115 % 10 = 5
So 60480-69-5 is a valid CAS Registry Number.

60480-69-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)acetamide

1.2 Other means of identification

Product number -
Other names Acetamide,N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60480-69-5 SDS

60480-69-5Downstream Products

60480-69-5Relevant articles and documents

Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles

Davies, David J.,Garratt, Peter J.,Tocher, Derek A.,Vonhoff, Stefan,Davies, John,Teh, Muy-Teck,Sugden, David

, p. 451 - 467 (1998)

Tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles, and hexahydrocyclohept[b]indoles have been prepared as melatonin analogues to investigate the nature of the binding site of the melatonin receptor. The affinity of analogues was compared in a radioligand binding assay using chicken brain membranes and agonist and antagonist potency measured in clonal Xenopus laevis melanophore cells. Comparison of the N-acyl-3-amino-6- methoxytetrahydrocarbazoles (2) with N-acyl-4-(aminomethyl)-6-methoxy-9- methyltetrahydrocarbazoles (9) showed that the latter have much higher binding affinities for the chicken brain receptor. Comparison of N-acyl-1- (aminomethyl)-7-methoxy-4-methyltetrahydrocyclopent[b]indoles (10), 6- methoxytetrahydrocarbazoles (9), and N-acyl-10-(aminomethyl)-2-methoxy-5- methylhexahydrocyclohept[b]indoles (11) showed that the tetrahydrocarbazoles had the highest binding affinity with the cyclohept-[b]indoles and the cyclopent[b]indoles having rather lower affinities. All of these observations are in agreement with our postulated model of melatonin orientation at the binding pocket in which the 3-amidoethane side chain is in a conformation close to the 5-methoxyl group, as is shown in the X-ray crystallographic structure of 9m and in the energy-minimized computed structures. Separation of the enantiomers of members from each of these three systems was accomplished by chiral HPLC. It was found that in all cases the (-)- enantiomer had a higher binding affinity than the (+)-enantiomer. An X-ray crystallographic analysis of the two enantiomers of 9a showed that the (+)- enantiomer had the (R) absolute stereochemistry. Since the sign of the Cotton curves, determined from circular dichroism studies, was the same for all (+)- enantiomers, it is assumed that the absolute stereochemistry at these centers is identical. In the Xenopus melanophore assay, the tetrahydrocarbazoles 2 (R = H) were mainly weak antagonists, while those with R = OMe were agonists. The biological behavior of the tetrahydrocarbazoles 9 (R = H) depended on R1, some being agonists and some antagonists, whereas those with R = OMe were generally agonists. Variation of the R and R1 groups in compounds of type 9 produced both agonists and antagonists. The tetrahydrocylopentaindoles 10 had similar biological properties to the corresponding analogues of 9, but the hexahydrocycloheptaindoles 11 showed a much greater propensity to be antagonists. In all cases the (S)-enantiomers were found to be more potent agonists than the (R)-enantiomers.

3-Hydroxy carbazole derivatives

-

, (2008/06/13)

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.

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