60481-34-7Relevant academic research and scientific papers
AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS
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Page/Page column 76, (2016/11/17)
The present invention relates to novel aminoindazolyl derivative compounds of Formula(I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.
9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma
Maiwald, Franziska,Benítez, Diego,Charquero, Diego,Dar, Mahin Abad,Erdmann, Hanna,Preu, Lutz,Koch, Oliver,H?lscher, Christoph,Loa?c, Nadège,Meijer, Laurent,Comini, Marcelo A.,Kunick, Conrad
supporting information, p. 274 - 283 (2014/07/08)
Trypanosomes from the "brucei" complex are pathogenic parasites endemic in sub-Saharan Africa and causative agents of severe diseases in humans and livestock. In order to identify new antitrypanosomal chemotypes against African trypanosomes, 4-azapaullone
Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
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Page/Page column 12, (2008/06/13)
The present application provides novel compounds according to Formula (I): including all stereoisomers, solvates, prodrug esters and pharmaceutically acceptable salt forms thereof, wherein R1, R4a, R5, R6, Rsup
Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites
Humber,Ferdinandi,Demerson,Ahmed,Shah,Mobilio,Sabatucci,De Lange,Labbadia,Hughes,DeVirgilio,Neuman,Chau,Weichman
, p. 1712 - 1719 (2007/10/02)
The syntheses of five metabolites of the antiinflammatory drug etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid) are described, viz. 6-hydroxyetodolac, N-methyletodolac, 4-ureidoetodolac, 8-(1'-hydroxy)etodolac, and 4-oxoetodolac. These syntheses were used to confirm the identities of the metabolites. The metabolites themselves, as well as the previously reported metabolite 7-hydroxyetodolac, were tested in a rat adjuvant edema model and in vitro for their capacity to block prostaglandin production in chondrocyte cells. All either were inactive or possessed only marginal activity. The isolation of N-methyletodolac and 4-oxoetodolac from human and rat urine, respectively, is also described.
