604813-08-3

Basic information

• Product Name: 4-CHLORO-N-ISOPROPYL-PYRIDINE-2-CARBOXAMIDE
• Synonyms: 4-Chloro-N-isopropylpicolinamide;4-chloro-N-(propan-2-yl)pyridine-2-carboxaMide;4-CHLORO-N-ISOPROPYL-PYRIDINE-2-CARBOXAMIDE
• CAS NO: 604813-08-3
• Molecular Formula: C₉H₁₁ClN₂O
• Molecular Weight: 198.64944
• Product Categories: Pyridines
• Mol File: 604813-08-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 331.6 °C at 760 mmHg
• Flash Point: 154.4 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.000154mmHg at 25°C
• Refractive Index: 1.531
• PKA: 13.11±0.46(Predicted)
• CAS DataBase Reference: 4-CHLORO-N-ISOPROPYL-PYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-ISOPROPYL-PYRIDINE-2-CARBOXAMIDE(604813-08-3)
• EPA Substance Registry System: 4-CHLORO-N-ISOPROPYL-PYRIDINE-2-CARBOXAMIDE(604813-08-3)

Safety Data

• Hazardous Substances Data: 604813-08-3(Hazardous Substances Data)

Usage

General Description

4-CHLORO-N-ISOPROPYL-PYRIDINE-2-CARBOXAMIDE, also known as 2-chloro-N-isopropylpicolinamide, is a chemical compound with the molecular formula C10H12ClN3O. It is a pyridine derivative and is primarily used as an intermediate in the synthesis of pharmaceutical and agrochemical compounds. This chemical is known for its broad application in the field of medicinal chemistry and crop protection due to its ability to inhibit enzymes and biological processes. It is also used in the production of various drugs and pesticides, making it an important chemical in the pharmaceutical and agricultural industries.

InChI:InChI=1/C9H11ClN2O/c1-6(2)12-9(13)8-5-7(10)3-4-11-8/h3-6H,1-2H3,(H,12,13)

Upstream product

• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 75-31-0 isopropylamine 
• 51727-15-2 4-chloropicolinoyl chloride hydrochloride 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 1412891-43-0 4-(3-(3-(4-chlorophenyl)thioureido)phenoxy)-N-isopropylpicolinamide 
• 1412891-61-2 N-isopropyl-4-(3-(3-(4-(trifluoromethoxy)phenyl)thioureido)phenoxy)picolinamide 
• 1412891-64-5 4-(3-aminophenoxy)-N-isopropylpicolinamide 

Relevant articles and documents

Styryl pyridine compound containing pyridine structure, preparation method and application of styryl pyridine compound in preparation of antitumor drugs (by machine translation)

The invention belongs to the field, and particularly relates to a styryl pyridine compound containing a pyridine structure, a preparation method and an application of the styryl pyridine compound in preparation of anti-tumor drugs, wherein the compound is a compound as shown in the formula I. The compound of the general formula I has good inhibitory activity on non-small cell lung cancer A549 and liver cancer cell HepepepG2, can be used for preparing antitumor drugs, and is especially suitable for cancers, kidney cancer, lung cancer, thyroid cancer, colon cancer and other tumors. (by machine translation)

The structure of the amine-containing thiourea compound and its preparation method and application

A disclosed thiourea compounds containing an arylamine structure comprises compounds of a general formula I and pharmaceutically acceptable salts. In the general formula I shown in the specification, R1 is selected from H, C1-C8 alkyl, halogens, -CF3, -OCF3, -NO2, -CN, R2O-, -SO2NH2, -NHSO2R3, -NR4R5, -CONR6R7, -COOR8, R9CO- and disubstituted and trisubstituted combinations thereof, R2, R3, R4, R5, R6, R7, R8 and R9 are respectively H or C1-C8 alkyl, L is selected from -NHR10, -NHOR11, -NR12R13, pyrrolidin-1-yl, 4-piperidyl and (4-methyl-1-piperazinyl)methylene, and R10, R11, R12 and R13 are respectively H, C1-C8 alkyl, cycloalkyl or aryl. The compounds have inhibiting effect on multiple tumor cell strains.

Design, synthesis and biological activities of sorafenib derivatives as antitumor agents

A series of novel sorafenib derivatives, 9a-w, was designed and synthesized in high yields using various substituted anilines, and their antiproliferative activities against HCT116, PC-3 and MDA-MB-231 cell lines were also evaluated and described. All compounds exhibited potent antiproliferative activity against HCT116 and PC-3 cells with IC50 = 2.8-52.0 and 2.2-45.6 μM; compounds 9p and 9q demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines, the cytotoxicity of compound 9r is more potent than that of sorafenib. Compounds (9g, 9p, 9q and 9r) were chosen for further evaluation of the anti-angiogenesis activity, and showed the inhibition of sprout formation from aortic ring ex vivo. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS.