60509-41-3Relevant academic research and scientific papers
Preparation and evaluation of reagents for tagging amino and thiol groups with fluorous stannanes. A convenient method for producing radioiodinated compounds in high effective specific activity
Donovan, Amanda C.,Valliant, John F.
experimental part, p. 65 - 71 (2011/09/30)
Building on the previously reported fluorous labeling strategy (FLS), a new approach for preparing molecular imaging and therapy agents derived from radioiodine in high purity without the need to employ HPLC was developed. A series of novel reagents conta
Benzylamines: Synthesis and evaluation of antimycobacterial properties
Meindl,Von Angerer,Schonenberger,Ruckdeschel
, p. 1111 - 1118 (2007/10/02)
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.
