60509-76-4Relevant academic research and scientific papers
METHOD FOR PRODUCING AMINE USING AMINE-BORANE
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Page/Page column 6-7, (2008/06/13)
PROBLEM TO BE SOLVED: To provide a reduction method for producing amines from imines using no solvent, and using an amine-borane which is a reducing agent that is stable and easy to handle. SOLUTION: The method for producing amines with a partial structure represented by formula 2 by reducing imines with a partial structure represented by formula 1 comprises using substantially no solvent, and using an amine-borane as a reducing agent.
One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions
Sato, Shinya,Sakamoto, Takeshi,Miyazawa, Etsuko,Kikugawa, Yasuo
, p. 7899 - 7906 (2007/10/03)
A one-pot reductive amination of aldehydes and ketones with amines using α-picoline-borane as a reducing agent is described. The reaction has been carried out in MeOH, in H2O, and in neat conditions in the presence of small amounts of AcOH. This is a highly efficient and mild procedure that is applicable for a wide variety of substrates. In particular, this is the first successful demonstration that this type of reaction can be carried out in water and in neat conditions.
Rhodium(I)-Sulfonated-bdpp Catalysed Asymmetric Hydrogenation of Imines in Aqueous-Organic Two-phase Solvent Systems
Bakos, Jozsef,Orosz, Arpad,Heil, Balint,Laghmari, Mohamed,Lhoste, Paul,Sinou, Denis
, p. 1684 - 1685 (2007/10/02)
The imines ArC(Me)=NCH2Ph (Ar = Ph, 2-MeO-C6H4, 3-MeO-C6H4, 4-MeO-C6H4) are hydrogenated to the corresponding amines with extremely high enantioselectivities up to 96percent under very mild conditions, using rhodium complexes associated with sulfonated bdpp.
Reduction of Schiff Bases with Isopropyl Alcohol and Aluminum Isopropoxide in the Presence of Raney Nickel
Botta, Maurizio,Angelis, Francesco De,Gambacorta, Augusto,Labbiento, Lucia,Nicoletti, Rosario
, p. 1916 - 1919 (2007/10/02)
The reduction of several N-alkyl and N-aryl ketimines to the corresponding secondary amines is described.The reaction, which generally proceeds in high yield, is effected by isopropyl alcohol and aluminium isopropoxide in the presence of Raney nickel.In the absence of the nickel catalyst, that is, under the Meerwein-Ponndorf-Verley conditions, the reaction takes a different route and N-isopropylamines are formed at preference to the direct reduction products.Without the aluminum alkoxide the reduction proceeds only for a small percentage.This reaction, besides offering a new method for the synthesis of secondary amines, represents the first example where the couple aluminum alkoxide/Raney nicel is used in catalytic transfer hydrogenation reactions.
