6052-84-2Relevant articles and documents
Synthesis of ethylene bis [(2-hydroxy-5,1,3-phenylene) bis methylene] tetraphosphonic acid and their anticorrosive effect on carbon steel in 3%NaCl solution
Sait,Aliouane,Toukal,Hammache,Al-Noaimi,Helesbeux,Duval
, (2021/01/25)
The inhibition performance of the newly synthesized Ethylene bis [(2-hydroxy-5,1,3-phenylene) bis methylene] tetraphosphonic acid (ETPA) toward carbon steel in 3% NaCl was investigated at different concentrations using potentiodynamic polarization (PDP) and impedance spectroscopy (EIS) methods. It was found that the inhibition capability was increased with increasing inhibitor dose and reach 92% at 10?3 mol/L. Also, Polarization curves showed that ETPA acts as a mixed type inhibitor with predominantly control of anodic reaction. The new inhibitor was investigated by different spectroscopic methods such as 1H, 13C and 31PNMR. The quantum parameters such as absolute electronegativity (χ), energy gap ΔE (EHOMO-ELUMO), global softness (σ), global hardness (η), electrophilicity index (ω) and the number of transfer electrons (ΔN) are calculated by density functional theory (DFT). The experimental also correlated with density functional theory results. The calculations show that ETPA has high density of negative charge located on the oxygen atoms of the phosphonate group facilitating the adsorption of ETPA on the surface of carbon steel. The inhibition efficiency of ETPA was discussed in terms of blocking of electrode surface by adsorption of ETPA molecules through active centers. The adsorption of ETPA on the surface of carbon steel obeyed the Langmuir isotherm paradigm.
COMPOUNDS, COJUGATES AND COMPOSITIONS FOR USE IN THE METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
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Paragraph 00130, (2020/03/23)
The invention provides a system for the delivery of dmgs across biological membranes, including conjugates thereof, processes for their preparation and methods for their use.
Method for preparation of bibenzyl compounds by photocatalytic one-step process
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Paragraph 0051-0054, (2019/07/04)
The invention relates to a brand new low-cost method for synthesis of bibenzyl compounds. The method adopts green and clean light energy as the reaction energy, and takes toluene or a toluene derivative as the raw material to prepare bibenzyl compounds under the catalysis of a solid photocatalyst. The method is carried out at room temperature, and can prepare bibenzyl compounds directly by illumination. The reaction process includes: mixing a toluene derivative, a catalyst and a solvent, then putting the mixture into a pressure-resistant quartz container (larger than 1MPa), and performing replacement with inert gas, conducting illumination stirring at room temperature, and carrying out reaction for 1 or more hour. At the end of the reaction, the catalyst can be easily separated from the reaction system and can be recycled repeatedly, the reaction product can be separated by crystallization, and the yield of bibenzyl compounds can reach 3.21g (g catalyst)h. The method can be used for direct preparation of 1, 2-diphenylethane and natural bibenzyl drugs.
Synthesis and fungicidal activity of bioactive 4,4′-bis[4″-(N-benzylidinylamine)-3″-mercapto-1″,2″,4″-triazole-5″-yl methoxy]dibenzyl
Dwivedi, Smriti,Singh, Pravin K.
, p. 19 - 21 (2016/12/22)
The reaction of 4,4′-diamino dibenzyl (I) with sodium nitrite and HCl at 0-5°C followed by hydrolysis gave 4,4′-dihydroxy dibenzyl (II), which on reaction with chloroacetic acid in presence of sodium carbonate yielded 4,4′-ethylenebisphenoxyacetic acid (I
Synthesis and structure–activity relationships of 1-benzylindane derivatives as selective agonists for estrogen receptor beta
Yonekubo, Shigeru,Fushimi, Nobuhiko,Miyagi, Takashi,Nakanishi, Osamu,Katsuno, Kenji,Ozawa, Motoyasu,Handa, Chiaki,Furuya, Noritaka,Muranaka, Hideyuki
supporting information, p. 5895 - 5910 (2016/10/30)
The estrogen receptor beta (ERβ) selective agonist is considered a promising candidate for the treatment of estrogen deficiency symptoms in ERβ-expressing tissues, without the risk of breast cancer, and multiple classes of compounds have been reported as
Synthesis of 4,4'-Bis (Pyrimidinedione Acetamidoxy) bibenzyls as antifungal agents
Dwivedi, Smriti,Siddiqui
, p. 433 - 436 (2019/01/21)
4,4'-Diaminobibenzyl (I) with sodium nitrite and HCl at 0-5° followed by hydrolysis gave 4,4'-dihydroxybibenzyl (II), which on reaction with chloroacetic acid in presence of sodium carbonate yielded 4,4'-ethylenebisphenoxyacetic acid (III). Nucleophilic s
Understanding the reactivity of enol ether radical cations: Investigation of anodic four-membered carbon ring formation
Yamaguchi, Yusuke,Okada, Yohei,Chiba, Kazuhiro
, p. 2626 - 2638 (2013/04/23)
The reactivity of enol ether radical cations was investigated in anodic four-membered carbon ring formations, advancing the mechanistic understanding of these reactions. The mono-ring-containing aromatic cations were reduced through inter- or intramolecular electron transfer to give mono- or bis-ring-containing compounds, respectively. Small structural changes in the hydrocarbon linkers tethering two aromatic rings exerted a powerful effect on the efficiency of such electron transfer events.
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta
Waibel, Michael,De Angelis, Meri,Stossi, Fabio,Kieser, Karen J.,Carlson, Kathryn E.,Katzenellenbogen, Benita S.,Katzenellenbogen, John A.
experimental part, p. 3412 - 3424 (2009/10/23)
A series of structurally simple bibenzyl-diol and stilbene-diol core molecules, structural analogs of the well-known hexestrol and diethylstilbestrol non-steroidal estrogens, were prepared and evaluated as estrogen receptor (ER) subtype-selective ligands. Analysis of their ERα and ERβ binding showed that certain substitution patterns engendered binding affinities that were >100-fold selective for ERβ. When further investigated in cell-based gene transcription assays, some molecules showed similarly high relative transcriptional potency selectivity in favor of ERβ. Interestingly, the most ERβ-selective molecules were those bearing non-polar substituents on one of the internal carbon atoms. These compounds should be useful probes for determining the physiological roles of ERβ, and they might lead to the development of more selective and thus safer pharmaceuticals.
STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES
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Page/Page column 172, (2015/06/03)
The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
Low-valent titanium mediated synthesis of hydroxystilbenoids: Some new observations
Shadakshari,Rele,Nayak,Chattopadhyay
, p. 1934 - 1938 (2007/10/03)
A series of phenolic stilbenoids possessing different numbers and positions of hydroxylation, partial methoxyl substituents and nature of olefinic moieties has been synthesized by McMurry coupling. It is found that the McMurry coupling of the phenolic aldehydes furnishes the dihydrostilbenes via an in situ hydrogenation, while the phenolic ketones give the stilbenes. Interestingly, the study also reveals that the low-valent titanium reagent (TiCl 3-Zn-THF) could selectively depyranylate phenolic -OTHP function without affecting alcoholic -OTHP group.
