60544-10-7

Basic information

• Product Name: 2-(2-methylphenyl)-1,4-naphthoquinone
• Synonyms: 2-(2-methylphenyl)-1,4-naphthoquinone
• CAS NO: 60544-10-7
• Molecular Weight: 248.281
• Mol File: 60544-10-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(2-methylphenyl)-1,4-naphthoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methylphenyl)-1,4-naphthoquinone(60544-10-7)
• EPA Substance Registry System: 2-(2-methylphenyl)-1,4-naphthoquinone(60544-10-7)

Safety Data

• Hazardous Substances Data: 60544-10-7(Hazardous Substances Data)

Upstream product

• 766-47-2 1-ethynyl-2-methylbenzene 
• 615-37-2 ortho-methylphenyl iodide 
• 130-15-4 [1,4]naphthoquinone 
• 108-88-3 toluene 
• 1374643-16-9 bis(2-methylphenyl)iodonium trifluoromethanesulfonic acid 
• 16419-60-6 2-Methylphenylboronic acid 

Relevant articles and documents

Synthesis of aryl- and alkylquinones through rhodium-catalyzed C-C coupling under mild conditions

A direct arylation, alkylation of quinones with aryl and alkyl boronic acids through rhodium-catalyzed C-C coupling has been developed under mild conditions. [CpRhCl2]2 was shown to be the most effective catalyst for the transformation. More importantly, good to excellent yields were obtained under room temperature and base-free conditions. This reaction provides a practical, efficient method for the synthesis of aryl- and alkylquinones.

CuI/Cu(OTf)2/DMSO system-catalyzed intramolecular oxidative cyclization of (o-alkynyl)arylketones: Efficient synthesis of 1,4-naphthoquinones

A concise and efficient method for the synthesis of 1,4-naphthoquinones has been successfully developed involving a CuI/Cu(OTf)2/DMSO system-catalyzed intramolecular oxidative cyclization of (o-alkynyl)arylketones. The present protocol provided a novel approach to access functionalized 1,4-naphthoquinones from non-naphthoquinone precursors with good selectivity and functional group tolerance.

Method for synthesizing 2-substituted-1,4-naphthoquinone compound

The invention discloses a method for synthesizing a 2-substituted-1,4-naphthoquinone compound. The method comprises the following steps: by taking a 2-alkynyl acetophenone compound of a formula I as shown in the specification as a raw material, in the presence of a copper catalyst, by taking Selectfluor as an oxidant, adding an alkali substance, performing a stirring reaction for 10-24 hours at 70 DEG C in a mixed solvent of acetonitrile and water, and after the reaction is completed, and performing aftertreatment on reaction liquid, thereby obtaining the 2-substituted-1,4-naphthoquinone compound of a formula II as shown in the specification. By adopting the method disclosed by the invention, the raw materials are variable, a great amount of derivatives can be generated, the catalyst is cheap and easy to obtain, the cost can be greatly lowered, and no pollution can be caused; oxygen sources used in the method are water and Selectfluor; the reaction condition is gentle, and energy consumption can be reduced; in addition, the method has the characteristics of being high in yield, good in substrate universality, simple and convenient in aftertreatment operation, and the like.