6055-19-2 Usage
Chemical Properties
White to Off-White Solid
Uses
Different sources of media describe the Uses of 6055-19-2 differently. You can refer to the following data:
1. It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.
2. antineoplastic, alkylating agent
3. alkylating agent in cancer therapy
4. An immunosuppressive, cytotoxic apoptosis inducer.
5. Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.
Definition
ChEBI: The monohydrate of cyclophosphamide.
General Description
Fine white crystalline powder with a slightly bitter taste. Little or no odor.
Air & Water Reactions
Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.
Reactivity Profile
Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.
Fire Hazard
Cyclophosphamide monohydrate is probably combustible.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Safety Profile
Confirmed human
carcinogen. Poison by ingestion and
intravenous routes. Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of Cl-, PO,, and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 6055-19-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,5 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6055-19:
(6*6)+(5*0)+(4*5)+(3*5)+(2*1)+(1*9)=82
82 % 10 = 2
So 6055-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2/t14-;/m1./s1