60556-85-6

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 5640, 1989 DOI: 10.1021/jo00284a050

Upstream product

• 61444-65-3 3-bromo-2,2-difluoropropanoyl chloride 
• 765-63-9 2,2,3,3-tetrafluorooxetane 
• 112753-67-0 α,β-Difluoropropionyl chloride 
• 41578-52-3 2,3,3-trifluoro-2-propen-1-ol 

Downstream Products

• 664342-20-5 N-allyl-N-benzyl-2-fluoroacrylamide 
• 484649-06-1 2-fluoro-bicyclo[2.2.1]hept-5-ene-2-carbonyl fluoride 
• 664342-21-6 N-benzyl-N-(but-3-enyl)-α-fluoroacrylamide 
• 46115-40-6 phenyl 2-fluoroacrylate 

Relevant academic research and scientific papers

Synthese von α-Fluoracrylsaeure und Derivaten

Three new routes to derivatives of α-fluoracrylic acid, including a laboratory synthesis and a large-scale method, are reported.The processes are (i) addition of elementary fluorine to acrylic esters and subsequent elimination of HF; (ii) addition of difluorocarbene to isopropenyl methyl ether, oxidation via ring opening and dehalogenation; and (iii) "nitrofluorination" of 2,3-dichloropropene, hydrolysis and dechlorination.

REACTION OF HALOGEN FLUORIDES. IX. SYNTHESIS OF DERIVATIVES OF α-FLUOROACRYLIC ACID

New methods have been proposed for the preparation of derivatives of α-fluoroacrylic acid by the substituent fluorination of 1,2-dibromo-3-chloropropane and methyl 2,3-dibromo-2-chloropropanoate with bromine trifluoride.

Processes for producing α-fluoroacrylic acid esters and α-fluoroacrylic acid fluoride

This invention provides a process for preparing an α-fluoroacrylic acid ester characterized by reacting 2,2,3,3-tetrafluorooxetane, a metal halide, an alcohol and a dehalogenating agent. This invention also provides a process for preparing α-fluoroacrylic acid fluoride, CH2 =CFCOF, which is an intermediate for preparing the α-fluoroacrylic acid ester.