60558-63-6Relevant academic research and scientific papers
The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase
Chen, Zexin,Marcé, Patricia,Resende, Ricardo,Alzari, Pedro M.,Frasch, A. Carlos,van den Elsen, Jean M.H.,Crennell, Susan J.,Watts, Andrew G.
, p. 25 - 33 (2018/09/13)
The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a promising target for the development of new drug treatments against Chagas' disease. Here we describe
A one-pot, three-step synthesis of α-aminophosphonic acids
Ryabukhin, Sergey V.,Panov, Dmitriy M.,Shivanyuk, Alexander N.,Plaskon, Andrey S.,Zarudnitskiy, Evgeniy N.,Lukin, Oleg
, p. 2079 - 2084 (2014/08/05)
A total of 20 α-aminophosphonic acids are synthesized in 73-89% yields via a one-pot, three-step procedure involving chlorotrimethylsilane- promoted condensation of carbonyl compounds and primary amines yielding azomethine intermediates, subsequent reaction with tris(trimethylsilyl) phosphite to give the corresponding trimethylsilylphosphonic esters and finally, mild cleavage with methanol-water. The wide scope and simple set-up and work-up procedures of the reported method allow the synthesis of a diverse set of α-aminophosphonic acids possessing two different functional groups. Georg Thieme Verlag Stuttgart, New York.
Reactions of Phosphonous Acid, Bis(trimethylsilyl) Phosphonite, and Bis(trimethylsilyl) Phosphonates with Schiff Bases
Pudovik, A. N.,Khairullin, V. K.,Saakyan, G. M.,Shagidullin, R. R.,Pudovik, M. A.,Vandyukova, I. I.,Musin, R. Z.
, p. 23 - 25 (2007/10/03)
Bis(trimethylsilyl) phosphonite adds to N-benzylideneaniline with formation of α-phenylaminobenzylphosphonite which is readily oxidized on exposure to air. Bis(trimethylsilyl) phosphonate with the same Schiff base forms trimethylsilyl hydrogen α-phenylami
