60586-66-5Relevant academic research and scientific papers
Copper catalysed alkynylation of tertiary amines with CaC2: Via sp3 C-H activation
Teong, Siew Ping,Yu, Dingyi,Sum, Yin Ngai,Zhang, Yugen
, p. 3499 - 3502 (2016)
A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide has been developed. The reaction proceeds via sp3 C-H bond activation and C-C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C-H reactivity.
Chemoselective C-H bond activation: Ligand and solvent free iron-catalyzed oxidative C-C cross-coupling of tertiary amines with terminal alkynes. Reaction scope and mechanism
Volla, Chandra M. Rao,Vogel, Pierre
supporting information; experimental part, p. 1701 - 1704 (2009/09/06)
FeCI2 catalyzes the oxidative C-C cross-coupling of tertiary amines with terminal alkynes Into propargylamlnes using (t-BuO)2 as oxidant. The reaction can be applied to aromatic and aliphatic amines and alkynes without solvent. High chemoselectlvlty for amlnomethyl groups Is due to a steric factor.
