60598-59-6

Upstream product

• 60-29-7 diethyl ether 
• 115057-41-5 cyanoacetyl azide 
• 100-63-0 phenylhydrazine 
• 105-56-6 ethyl 2-cyanoacetate 
• 16130-58-8 cyanoacetic acid chloride 

Downstream Products

• 106473-46-5 1-anilino-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 70373-98-7 5-amino-1-phenyl-1H-pyrazol-3(2H)-one 
• 60598-72-3 3-anilino-5,6,7,8-tetrahydro-1H-spiro[benzo[4,5]thieno[2,3-d]pyrimidine-2,1'-cyclohexan]-4-one 
• 64686-94-8 4-amino-3-phenyl-2-thioxo-2,3-dihydro-thiazole-5-carboxylic acid N'-phenyl-hydrazide 
• 64687-04-3 6-anilino-3-ethyl-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one 
• 1219609-14-9 5-amino-3-anilino-1,10b-dihydro-2H-chromeno[3,4-c]pyridine-2,4(3H)-dione 
• 1296687-67-6 7,7-dimethyl-2,5-dioxo-1-phenylamino-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1296687-82-5 7-furan-2-yl-2,5-dioxo-1-phenylamino-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1296687-92-7 3-hydroxy-7,7-dimethyl-1-phenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b]quinolin-5-one 
• 1296687-98-3 7-furan-2-yl-3-hydroxy-1-phenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b]quinolin-5-one 
• 1296688-00-0 1-(4-fluoro-phenyl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydro-quinoline-3-carboxylic acid N'-phenyl-hydrazide 
• 1296688-02-2 1-(3-chloro-phenyl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydro-quinoline-3-carboxylic acid N'-phenyl-hydrazide 
• 1296688-04-4 1-(2-methoxy-phenyl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydro-quinoline-3-carboxylic acid N'-phenyl-hydrazide 
• 1296688-15-7 7,7-dimethyl-2,5-dioxo-1-phenylamino-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid amide 

Relevant academic research and scientific papers

Pathways for cyclizations of hydrazine-derived 2-(2-cyanovinyl)-3-oxo- cyclohex-1-ene enolates

The introduction of a hydrazine functionality into 2-(2-cyanovinyl)-3-oxo- cyclohex-1-ene enolates results in their spontaneous cyclizations with participation of the hydrazine moiety. Depending on the reaction conditions used, the hydrazine-derived enola

Synthesis and antimicrobial activity of pyridopyrazole and pyrazolo[3,4-d]dihydrothiazole

6-Methyl-1,3-dihydro-4H,7H-pyrazolo[2,3-c]pyridine-4-one (4) were synthesized by microwave as well as conventional method. The reaction time reduced 10 times than that of conventional method. The pyrazolo[3,4-d] dihydrothiazole (8) were synthesized by reacting phenylisothiocyanate with 1-carbethoxy-5-amino-pyrazol-4-ene-3-one and were screened for their antimicrobial activities.

Modulators of LXR

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.