606080-44-8 Usage
General Description
Methyl 2-(aminomethyl)-5-fluorobenzoate hydrochloride, also known as flumazenil, is a chemical compound that acts as a selective competitive antagonist of the benzodiazepine receptor. It is commonly used as an antidote for benzodiazepine overdose and to reverse the effects of sedation and anesthesia induced by benzodiazepines. Flumazenil works by binding to the benzodiazepine receptor and blocking the effects of benzodiazepines, effectively reversing their sedative and hypnotic effects. It is available in injectable form for emergency use and has a relatively fast onset of action, making it a valuable tool in managing benzodiazepine overdose. Methyl 2-(aMinoMethyl)-5-fluorobenzoate hydrochloride is important in the medical field for its ability to quickly and effectively reverse the effects of benzodiazepines, which can be life-saving in certain overdose situations.
Check Digit Verification of cas no
The CAS Registry Mumber 606080-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,6,0,8 and 0 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 606080-44:
(8*6)+(7*0)+(6*6)+(5*0)+(4*8)+(3*0)+(2*4)+(1*4)=128
128 % 10 = 8
So 606080-44-8 is a valid CAS Registry Number.
606080-44-8Relevant articles and documents
Copper-catalyzed C-N coupling in the synthesis of integrase inhibitors of immunodeficiency viruses
Lin, Jinguan,Houpis, Ioannis N.,Liu, Renmao,Wang, Youchu,Zhang, Jianqian
, p. 205 - 214 (2014/05/20)
This contribution describes the total synthesis of a complex macrocyclic integrase inhibitor, a key enzyme involved in the infection process of various immunodeficiency viruses. The key transformation of the synthetic strategy was the selective C-N coupling of a sulfonamide to a heteroaryl bromide in the presence of potentially competing amide and carbamate functionalities. The transformation was accomplished with CuI catalysis using bypiridine as the ligand in the presence of base and enabled a convergent approach to the target molecule.
Preparation of 2-aminomethyl-5-fluorobenzamides
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Page 17, (2008/06/13)
Benzamide compounds of Formula VII are prepared by reacting a benzoate compound of Formula V with an amine to obtain a benzamide compound of Formula VI, and then treating the benzamide VI with an amine deprotecting agent to obtain the benzamide VII; where
