60609-68-9Relevant academic research and scientific papers
Chemoselective Benzylation of Aldehydes Using Lewis Base Activated Boronate Nucleophiles
Hollerbach, Michael R.,Barker, Timothy J.
, p. 1425 - 1427 (2018/05/24)
A benzylation of aldehydes using primary and secondary benzylboronic acid pinacol esters is reported. Activation of the boronic ester with s-butyllithium rendered it nucleophilic toward aldehydes. The activated nucleophile chemoselectively transfers the benzyl group over the sec-butyl group, providing excellent yields of the benzylated products. 11B NMR experiments were performed to study the mechanism of this transformation.
Nickel-catalyzed reductive benzylation of aldehydes with benzyl halides and pseudohalides
Panahi, Farhad,Bahmani, Marzieh,Iranpoor, Nasser
, p. 1211 - 1220 (2015/04/22)
The reductive benzylation of aromatic and aliphatic aldehydes with benzylic halides is reported using a nickel/zinc catalyst system. In addition to benzylic halides, the first report on the addition of benzylic triflates, acetates, tosylates and tritylates to aldehydes is also presented. By this new method a range of alcohols was synthesized efficiently from aldehydes and benzylic substrates at room temperature in moderate to high yields. The mild reaction conditions and good functional group tolerance make this nickel-catalyzed process synthetically useful for the synthesis of diverse benzylic alcohols.
Catalyst-controlled highly selective coupling and oxygenation of olefins: A direct approach to alcohols, ketones, and diketones
Su, Yijin,Sun, Xiang,Wu, Guolin,Jiao, Ning
supporting information, p. 9808 - 9812 (2013/09/23)
Oxygen? That's radical! A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst-controlled highly chemoselective coupling and oxygenation of olefins has been developed. The method is simple and practical, can be switched by the selection of different catalysts, and employs molecular oxygen as both an oxidant and a reagent. Copyright
Nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids
Nielsen, Daniel K.,Doyle, Abigail G.
supporting information; experimental part, p. 6056 - 6059 (2011/09/13)
Let's get multicatalytic! A Ni0 catalyst complexed with a biaryldialkyl monophosphine ligand facilitates C-C bond formation between styrenyl epoxides and aryl boronic acids (see scheme). X-ray analysis of a catalytically active nickel/ligand complex supports a redox pathway involving C sp 3-O bond activation. A variety of α-substituted alcohols were generated with good reaction efficiency by a multicatalytic sequence. Copyright
Regioselective ring-opening reaction of unsymmetrical 2,3-diaryl epoxides via catalytic hydrogenolysis with Pd(0)EnCatTM
Kimachi, Tetsutaro,Nagata, Hiroyo,Kobayashi, Yusuke,Takahashi, Kaori,Torii, Eri,Ju-Ichi, Motoharu
experimental part, p. 365 - 368 (2011/04/15)
A series of unsymmetrical 2,3-diaryl epoxides were hydrogenated under transfer-hydrogenation conditions using the polyurea-encapsulated palladium catalyst [Pd(0)EnCatTM]. The position of the cleaved C-O bond was determined by 1H NMR analysis of the ring-opened products derived from the epoxide, in which one of the two benzylic methyne protons is deuterated. The ratio of ring-opened products of the unsymmetrically substituted 2,3-diaryl epoxides was affected by the degree of the steric bulkiness on the aromatic ring. Georg Thieme Verlag Stuttgart New York.
