606099-87-0Relevant academic research and scientific papers
Discovery of small molecule RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis
Harris, Philip A.,Bandyopadhyay, Deepak,Berger, Scott B.,Campobasso, Nino,Capriotti, Carol A.,Cox, Julie A.,Dare, Lauren,Finger, Joshua N.,Hoffman, Sandra J.,Kahler, Kirsten M.,Lehr, Ruth,Lich, John D.,Nagilla, Rakesh,Nolte, Robert T.,Ouellette, Michael T.,Pao, Christina S.,Schaeffer, Michelle C.,Smallwood, Angela,Sun, Helen H.,Swift, Barbara A.,Totoritis, Rachel D.,Ward, Paris,Marquis, Robert W.,Bertin, John,Gough, Peter J.
, p. 1238 - 1243 (2014/01/06)
Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II class recognizing a DLG-out inactive conformation, were identified from screening of our in-house ki
Kinase inhibitors
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, (2008/06/13)
The present application is directed to pyrazolopyrimidine and furopyrimnidine analogs of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
