64611-67-2

Basic information

• Product Name: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE
• Synonyms: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE;2-Hydroxy-1-(4-nitrophenyl)ethanone;2-Hydroxy-4'-nitroacetophenone;2-hydroxy-1-(4-nitrophenyl)ethan-1-one;Ethanone, 2-hydroxy-1-(4-nitrophenyl)-
• CAS NO: 64611-67-2
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• Mol File: 64611-67-2.mol
• Article Data: 31

Chemical Properties

• Melting Point: 140-143°C
• Boiling Point: 338.4°C at 760 mmHg
• Flash Point: 152.6°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 3.84E-05mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.42±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE(64611-67-2)
• EPA Substance Registry System: 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE(64611-67-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 64611-67-2(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE, also known as p-Nitrophenylacetone, is a chemical compound with a molecular formula of C8H7NO4. It is a pale yellow crystalline solid that is commonly used in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also a key intermediate in the manufacturing of various chemicals, including pesticides and insecticides. Additionally, it has been reported to possess analgesic and anti-inflammatory properties, making it potentially useful for medicinal purposes. However, it is important to note that 2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE may pose health risks if not handled and used properly, as it is classified as a hazardous chemical.

InChI:InChI=1/C8H7NO4/c10-5-8(11)6-1-3-7(4-2-6)9(12)13/h1-4,10H,5H2

Upstream product

• 99-81-0 4-Nitrophenacyl bromide 
• 110944-98-4 2-iodo-1-(4-nitrophenyl)ethanone 
• 2712-78-9 bis-[(trifluoroacetoxy)iodo]benzene 
• 100-13-0 4-nitrostyrene 
• 124-41-4 sodium methylate 
• 34006-49-0 2-chloro-1-(4-nitrophenyl)ethanone 
• 78812-73-4 C₁₀H₁₃NO₅ 
• 132531-70-5 (+/-)_S-2-(4-nitrophenyl)-1-(phenylsulfinyl)ethene 
• 77977-75-4 p-nitrophenylethylene glycol 
• 6388-74-5 p-Nitrophenyloxirane 
• 100-19-6 (4-nitrophenyl)ethanone 
• 132531-91-0 2-(4-nitrophenyl)-1-(phenylsulfenyl)-1,2-bis(trifluoroacetoxy)ethane 
• 4203-31-0 2-diazo-1-(4-nitrophenyl)ethanone 

Downstream Products

• 77977-74-3 (S)-(+)-1-(4-nitrophenyl)-1,2-ethanediol 
• 62-23-7 4-nitro-benzoic acid 
• 69322-20-9 3-<2-(4-nitrophenyl)-2-oxoethyl>isobenzofuran-1(3H)-one 
• 112534-18-6 1-(4-aminophenyl)-1,2-ethanediol 
• 77977-75-4 p-nitrophenylethylene glycol 

Relevant articles and documents

Palladium-Catalyzed Diastereoselective Formal [5 + 3] Cycloaddition for the Construction of Spirooxindoles Fused with an Eight-Membered Ring

A Pd-catalyzed formal [5 + 3] intermolecular cycloaddition reaction of isatin-derived α-(trifluoromethyl)imines with aryl substituted vinylethylene carbonates (VECs) has been reported, affording trifluoromethyl-group-containing spirooxindoles fused with an eight-membered ring as a single diastereoisomer in good yields in the presence of a Br?nsted acid in a one-pot manner under mild conditions. The asymmetric version of this reaction has been also realized using a chiral phosphine ligand along with the further transformation of the obtained product to give a spirooxindolo pyrrolidine derivative upon oxidation.

Direct Aerobic Oxidative Reactions of 2-Hydroxyacetophenones

Valuable and direct aerobic oxidation reactions of 2-hydroxyacetophenones were explored. The concept was based on the in situ treatment of small quantities of aerobically formed α-keto aldehydes that drove the reactions to the corresponding products. This new strategy was applied for a variety of oxidative reactions of 2-hydroxyacetophenones, and valuable products such as phthalides, quinoxalines, and α-keto amides were obtained in good to high yields.

Investigation and Application of Amphoteric α-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement

In situ generation of the reactive amphoteric α-amino aldehyde with simple α-hydroxy ketones and phenylamine via Heyns rearrangement was proven to be feasible. Metal-free domino reactions based on this reactive intermediate were effectively used to afford important N-heterocycles including polysubstituted pyrroles, indoles, and quinoxalines conveniently. A simple starting material, water as the only byproduct, and diversity of the useful products will make this method greatly attractive for pharmaceutics.