2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

Base Information

• Chemical Name: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
• CAS No.: 60611-24-7
• Molecular Formula: C8H4 F4 O
• Molecular Weight: 192.113
• Hs Code.: 2913000090
• Mol file: 60611-24-7.mol

Synonyms:2-Fluoro-6-(trifluoromethyl)benzaldehyde;2-Trifluoromethyl-6-fluorobenzaldehyde; 6-Fluoro-2-trifluoromethylbenzaldehyde

Chemical Property of 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.572mmHg at 25°C
• Melting Point: 155-157°C
• Refractive Index: n20/D 1.458(lit.)
• Boiling Point: 189.4 °C at 760 mmHg
• Flash Point: 82 ºC
• PSA: 17.07000
• Density: 1.432
• LogP: 2.65700
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-6-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Fluoro-6-(trifluoromethyl)benzaldehyde may be employed for the synthesis of diaryl ether, 2-(3,5-dimethoxyphenoxy)-6-(trifluoromethyl)- benzonitrile and substituted benzo[b]thiophene-2-carboxylates.

Technology Process of 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

There total 3 articles about 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

3-fluoro-trifluoromethylbenzene (401-80-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-fluoro-6-(trifluoromethyl)benzaldehyde (60611-24-7)

Guidance literature:

3-fluoro-trifluoromethylbenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -70 - 78 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; Temperature;

Reference yield:

3-fluoro-trifluoromethylbenzene (401-80-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-fluoro-6-(trifluoromethyl)benzaldehyde (60611-24-7) + 2-(trifluoromethyl)-4-fluorobenzaldehyde (90176-80-0)

Guidance literature:

3-fluoro-trifluoromethylbenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

N,N-dimethyl-formamide; at -78 ℃; Reagent/catalyst; Temperature; Time; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.098

Reference yield:

→ 2-fluoro-6-(trifluoromethyl)benzaldehyde (60611-24-7)

Guidance literature:

entspr. Benzolderivat, HCOH;

upstream raw materials:

3-fluoro-trifluoromethylbenzene

N,N-dimethyl-formamide

Downstream raw materials:

ethyl (2E)-3-(2-fluoro-6-trifluoromethylphenyl)propenoate

2-fluoro-6-(trifluoromethyl)benzoic acid

4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid

4-((R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-trifluoromethylbenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-yl]-1-phenylethylamino)butyric acid ethyl ester