60611-68-9Relevant academic research and scientific papers
A New Simple Synthesis of Fusaric Acid and Other 5-Alkyl-2-pyridinecarboxylic Acids
Langhals, Elke,Langhals, Heinz,Ruechardt, Christoph
, p. 930 - 949 (2007/10/02)
Carboxamido groups are introduced into the 6-position of 3-acylpyridines with high regioselectivity via Minisci reaction with formamides, Fe(II) sulfate and tert-butyl hydroperoxide.The isolation procedure is considerably improved by the addition of citric acid for complexation of the Fe ions.Fusaric acid and other 5-alkyl-2-pyridine carboxylic acids are obtained by a following Wolff-Kishner reaction in 20-75percent overall yield.
SYNTHESIS OF 5-(SUBSTITUTED ALKYL)PICOLINIC ACIDS, THE DOPAMINE β-HYDROXYLASE INHIBITORS. III
Miyano, Koichi,Sakasai, Takeji,Hamano, Hiroaki
, p. 755 - 760 (2007/10/02)
Several 5-alkylpicolinic acids, dopamine β-hydroxylase inhibitors were synthesized from 2-cyclopropyl-5-cyclopropylcarbonylpyridine (I) as a suitable starting material.
5-Benzylpicolinic acid derivatives
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, (2008/06/13)
5-Benzy-2-pyridine carboxylic acids, in which the benzyl group is optionally substituted by one or two like or different alkyl, halo, alkoxy, nitro, amino, acetamido, hydroxy or acetoxy groups, and the corresponding amides and esters, possess dopamine β-h
