60612-23-9

Basic information

• Product Name: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE
• Synonyms: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HCL;N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE;N-[(2-chlorophenyl)methyl]thiophene-2-ethylamine hydrochloride;N-(2-Chlorobenzyl)-2-(-2-thienty)ethylamine Hydrochloride
• CAS NO: 60612-23-9
• Molecular Formula: C₁₃H₁₄ClNS*ClH
• Molecular Weight: 288.24
• EINECS: 262-327-7
• Mol File: 60612-23-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 143 °C
• Boiling Point: 359.9°C at 760 mmHg
• Flash Point: 171.5°C
• Appearance: /
• Vapor Pressure: 2.3E-05mmHg at 25°C
• CAS DataBase Reference: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(60612-23-9)
• EPA Substance Registry System: N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE(60612-23-9)

Safety Data

• Hazardous Substances Data: 60612-23-9(Hazardous Substances Data)

Usage

Uses

N-(2-Chlorobenzyl)-2-(2-thienyl)ethylamine is an intermediate used to prepare acid addition salts of 4, 5, 6, 7 - tetrahydrothieno (3,2-c) pyridine derivatives having antithrombotic activity.

InChI:InChI=1/C13H14ClNS.ClH/c14-13-6-2-1-4-11(13)10-15-8-7-12-5-3-9-16-12;/h1-6,9,15H,7-8,10H2;1H

Upstream product

• 75-21-8 oxirane 
• 98-59-9 p-toluenesulfonyl chloride 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 40412-06-4 2-(2-thienyl)ethyl tosylate 
• 5402-55-1 2-thiophenethanol 
• 2786-07-4 2-thienyl lithium 
• 143810-09-7 N-(2-chlorobenzyl)-2,2-dioxo-1,2,3-oxathiazolidine 

Downstream Products

• 53885-35-1 ticlopidine hydrochloride 

Relevant articles and documents

Novel preparation method for ticlopidine hydrochloride

The invention provides a novel preparation method for ticlopidine hydrochloride. The method comprises the following steps: with thiopheneethanol as a raw material, reacting thiopheneethanol with p-toluene sulfonyl chloride under the action of an acid binding agent so as to protect and activate a hydroxyl group; then subjecting a reaction product obtained in the previous step and o-chlorobenzylamine to a condensation reaction; and carrying out a ring closure reaction on a condensation reaction product and 1,3-dioxolane so as to obtain ticlopidine hydrochloride. The novel preparation method has the advantages of mild reaction conditions, low production cost, high product yield, good product quality and easy realization of industrial production.

Method for preparing ticlopidine hydrochloride

The invention provides a method for preparing ticlopidine hydrochloride, which comprises the following steps: reacting thienyl ethanol used as a raw material with paratoluensulfonyl chloride under the action of an acid-binding agent to protect and activate the hydroxy group; carrying out condensation reaction with ortho-chlorobenzylamine; and carrying out cyclization reaction with 1,3-dioxolane under acidic conditions to obtain the ticlopidine hydrochloride. The method has the advantages of mild reaction conditions, low production cost, high product yield and good product quality, and is convenient for industrial production.

N-2-chlorobenzyl-2-oxo and N-2-chlorobenzyl-2,2-dioxo-1,2,3-oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2-c]pyridine derivatives therefrom

Compounds of the formula: STR1 wherein: A is oxo or dioxo; R1, R2 and R3 are independently hydrogen or lower alkyl of one to six carbon atoms; R4, R5, R6 and R7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo; are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.