606142-98-7Relevant academic research and scientific papers
Asymmetric dihydroxylation of vinyl sulfones: Routes to enantioenriched α-hydroxyaldehydes and the enantioselective syntheses of furan-2(5H)-ones
Evans, Paul,Leffray, Mélanie
, p. 7973 - 7981 (2007/10/03)
The asymmetric dihydroxylation of α,β-unsaturated sulfones under Sharpless conditions affords enantioenriched α-hydroxyaldehydes in a complex mixture of dimeric species. These mixtures undergo olefination generating the corresponding α,β-unsaturated esters or furan-2(5H)-ones with high levels of enantiomeric excess. The application of this method for the rapid stereoselective synthesis of the furanone natural products; quercus lactone and maritolide, are described.
