60624-39-7

Basic information

• Product Name: 2-AMINO-N-(4-ETHYL-PHENYL)-BENZAMIDE
• Synonyms: 2-AMINO-N-(4-ETHYL-PHENYL)-BENZAMIDE;2-amino-N-(4-ethylphenyl)benzamide hydrochloride;AG-205/05987056;BAS 00159603;Enamine_005778;IDI1_008013;Oprea1_018398;Oprea1_384355
• CAS NO: 60624-39-7
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.3
• Mol File: 60624-39-7.mol

Chemical Properties

• Boiling Point: 338.8°Cat760mmHg
• Flash Point: 158.7°C
• Appearance: /
• Density: 1.181g/cm³
• Vapor Pressure: 9.6E-05mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 2-AMINO-N-(4-ETHYL-PHENYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(4-ETHYL-PHENYL)-BENZAMIDE(60624-39-7)
• EPA Substance Registry System: 2-AMINO-N-(4-ETHYL-PHENYL)-BENZAMIDE(60624-39-7)

Safety Data

• Hazardous Substances Data: 60624-39-7(Hazardous Substances Data)

Usage

Classification

Organic compound, benzamide

Functional groups

Primary amine group, amide functional group

Substituents

Ethyl-substituted phenyl group

Potential applications

Chemical research, pharmaceutical and medicinal chemistry

Specific uses and effects

Not widely studied and reported

InChI:InChI=1/C15H16N2O/c1-2-11-7-9-12(10-8-11)17-15(18)13-5-3-4-6-14(13)16/h3-10H,2,16H2,1H3,(H,17,18)

Upstream product

• 118-48-9 isatoic anhydride 
• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 60624-47-7 2-(2,2-Dicyano-vinylamino)-N-(4-ethyl-phenyl)-benzamide 
• 19826-42-7 3-(4-ethylphenyl)-2-methylquinazolin-4(3H)-one 
• 22874-41-5 3-(4-ethylphenyl)quinazolin-4(3H)-one 
• 133040-88-7 2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-ethyl-phenyl)-3H-quinazolin-4-one 
• 60624-42-2 (E)-2-Cyano-3-[2-(4-ethyl-phenylcarbamoyl)-phenylamino]-acrylic acid ethyl ester 

Relevant articles and documents

Ionic liquid supported on magnetic nanoparticles as a novel reusable nanocatalyst for the efficient synthesis of tetracyclic quinazoline compounds

A magnetic ionic liquid supported on γ-Fe2O3 nanocatalyst was synthesized successfully and characterized by Fourier transform infrared spectroscopy, vibrating sample magnetometry, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. The resulting nano-Fe3O4-supported, ionic liquid was an efficient catalyst for preparation of a series of tetracyclic quinazoline compounds by three components reaction of a mixture of isatoic anhydride and amine with ninhydrin in PEG and the desired products were obtained in good to excellent yields. High efficiency, waste-free, mild reaction conditions, effortless magnetic recovery and reusability up to four continuous cycles are the noteworthy features of the currently employed heterogeneous catalytic system.

Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system

Anticoagulant agents have emerged as a promising class of therapeutic drugs for the treatment and prevention of arterial and venous thrombosis. We investigated a series of novel orally active factor Xa inhibitors designed using our previously reported conjugation strategy to boost oral anticoagulant effect. Structural optimization of anthranilamide derivative 3 as a lead compound with installation of phenolic hydroxyl group and extensive exploration of the P1 binding element led to the identification of 5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide (33, AS1468240) as a potent factor Xa inhibitor with significant oral anticoagulant activity. We also reported a newly developed Free-Wilson-like fragment recommender system based on the integration of R-group decomposition with collaborative filtering for the structural optimization process.

Montmorillonite K-10 catalysed solvent-free synthesis of 2,3-disubstituted-4(3H)quinazolinones under microwave irradiation

An efficient and rapid synthesis of 2,3-disubstituted-4(3H)quinazolinones by condensation of 2-aminobenzamide (substituted anthraniamides) with orthoesters in the presence of K-10 clay under solvent free conditions using microwave irradiation or classical heating is described.