22874-41-5

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-(4-ethylphenyl)-
• CAS NO: 22874-41-5
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Mol File: 22874-41-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-(4-ethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-(4-ethylphenyl)-(22874-41-5)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-(4-ethylphenyl)-(22874-41-5)

Safety Data

• Hazardous Substances Data: 22874-41-5(Hazardous Substances Data)

Upstream product

• 60624-39-7 2-amino-N-(4-ethylphenyl)benzamide 
• 122-51-0 orthoformic acid triethyl ester 
• 107-21-1 ethylene glycol 
• 118-48-9 isatoic anhydride 
• 589-16-2 4-aminoethylbenzene 
• 118-92-3 anthranilic acid 
• 64-18-6 formic acid 

Downstream Products

• 19826-42-7 3-(4-ethylphenyl)-2-methylquinazolin-4(3H)-one 

Relevant articles and documents

One-pot synthesis of mono- and disubstituted (3H)-quinazolin-4-ones in dry media under microwave irradiation

AlCl3/ZnCl2 mixture supported on silica gel is an efficient medium for one-pot synthesis of (3H)-quinazolin-4-ones in the absence of solvent under microwave irradiation or classical heating. The reaction of orthoesters with 2-aminobenzamides ends up with the formation of monosubstituted (3H)-quinazolin-4-ones. One-pot synthesis of disubstituted (3H)-quinazolin-4- ones is also achieved by the reaction of isatoic anhydride with primary amines and orthoesters.

KAl(SO4)2·12H2O (Alum) catalyzed one-pot three-component synthesis of 2-alkyl and 2-aryl-4(3H)-quinazolinone under microwave irradiation and solvent free conditions

Twenty 2,3-disubstituted-4(3H)-quinazolinones were synthesed by one-pot three-component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO4)2·12H 2O (Alum) under microwave irradiation and solvent-free conditions. 6-Bromo-2-propyl-3-p-tolylquinazolin-4(3H)-one (4m), 6-bromo-2-methyl-3- phenethylquinazolin-4(3H)-one (4n) and 6-bromo-2-ethyl-3-phenethylquinazolin- 4(3H)-one (4o) were characterized by IR, 1H NMR, 13C NMR and elemental analysis. Twenty 2,3-disubstituted-4(3H)-quinazolinones were synthesed by one-pot three-component method with isatoic anhydride, orthoesters and amines as raw materi-als in the presence of KAl(SO4) 2·12H2O (Alum) under microwave irradiation and solvent-free conditions. 6-Bromo-2-propyl-3-p-tolylquinazolin-4(3H)-one (4m), 6-bromo-2-methyl-3-phenethylquinazolin-4(3H)-one (4n) and 6-bromo-2-ethyl-3- phenethylquina-zolin-4(3H)-one (4o) were characterized by IR, 1H NMR, 13C NMR and elemental analysis. Copyright

One-pot Synthesis of Substituted Quinazolin-4(3H)-ones under Microwave Irradiation

Synthesis of the title compounds by cyclocondensation of anthranilic acid, formic acid (or orthoesters) and an amine in one pot under microwave irradiation takes place in a few minutes.