60632-18-0

Usage

Uses

Used in Pharmaceutical Industry:
3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide is used as a key intermediate in the synthesis of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)oxazoles, which are anti-atherosclerotic agents. These agents are designed to combat atherosclerosis, a condition characterized by the hardening and narrowing of arteries, which can lead to heart disease and stroke.
In the preparation of these oxazoles, 3,5-Di-tert-butyl-4-hydroxybenzamide serves as a starting material, undergoing a series of chemical reactions to form the final product. The presence of the tert-butyl groups and the hydroxyl group in the molecule contributes to the stability and activity of the resulting anti-atherosclerotic agents, making them more effective in treating atherosclerosis and its associated complications.

Upstream product

• 40056-43-7 3,5-di-tert-butyl-4-hydroxybenzoyl chloride 
• 1421-49-4 3,5-Di-tert-butyl-4-hydroxybenzoic acid 
• 787-13-3 3,5-di-tert-butyl-4-hydroxybenzaldehyde oxime 
• 1988-88-1 2,6-di-tert-butyl-4-cyanophenol 

Downstream Products

• 114522-42-8 5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,3,4]oxathiazol-2-one 
• 1988-88-1 2,6-di-tert-butyl-4-cyanophenol 

Relevant academic research and scientific papers

2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

The invention encompasses compounds of Formula I or pharmaceutically acceptable salts thereof, which are modulators of the CXCR3 chemokine receptor function useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.

NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS

This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.

Compounds useful as neuro-protective agents

This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.

Method for treating pain

The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain.

Method for treating neuropathic pain

The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles.

Use of phenyl oxazole or phenyl thiazole derivatives for treating neuropathic pain

The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles.

Method for treating pain

The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain.

Use of phenyl oxazole or phenyl thiazole derivatives for treating pain

The present invention provides a method for treating pain comprising administering to an animal in need of such treatment, an analgesic dosage of certain phenyl oxazoles or phenyl thiazoles.

Crystal Engineering and Substituent Effect of Hindered Phenols for SHG Materials

2,6-di-tert-butylphenol moiety was found to be effective to control molecular packing in crystals for SHG materials.Many derivatives having compact acceptor group at 4-position of hindered phenols showed SHG responses depending on the electron withdrawing effect of an acceptor.The X-ray structural analyses revealed that molecular packing was controlled both by the steric requirements and the intermolecular hydrogen bonding.

Alkylamides of hindered 3,5-dialkyl-4-hydroxybenzoic acids and use as light stabilizers in polyolefins

Compounds of the formula: SPC1 Wherein R1 and R2 are each branch-chain alkyl of 3 to 8 carbon atoms and R3 and R4 are each hydrogen, alkyl of 1 to 18 carbon atoms, or cycloalkyl of 5 or 6 carbon atoms are useful as light stabilizers in polyolefins. They may be prepared (a) by reacting the 3,5-di-alkyl-4-hydroxybenzoyl chloride with the appropriate amine in the presence of an acid acceptor or (b) by reacting the corresponding benzoic acid with the appropriate amine in the presence of a carbodiimide as dehydrating agent.