6064-76-2Relevant academic research and scientific papers
Donepezil ether palmitate or its pharmaceutically acceptable salt
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Paragraph 0102-0104; 0111-0113, (2021/03/23)
The present invention relates to novel donepezil ether palmitate or a pharmaceutically acceptable salt thereof, and a sustained-release pharmaceutical composition comprising the same as a main component. The donepezil ether palmitate of the present invention introduces an ether palmitate group to donepezil, thereby reducing the initial release of the active ingredient, donepezil, when administered in the body, reducing the risk of side effects such as drug toxicity, etc., and allowing uniform release of donepezil for long period of time to improve the drug treatment effect on dementia patients.
Long-chain triazolyl acids as inhibitors of osteoclastogenesis
Marshall, Andrew J.,Lin, Jian-Ming,Grey, Andrew,Reid, Ian R.,Cornish, Jillian,Denny, William A.
, p. 4112 - 4119 (2013/07/27)
Saturated fatty acids (e.g., palmitic acid) are known to moderately inhibit the development of osteoclasts in vitro. In pursuit of more effective inhibitors of osteoclastogenesis we explored two new classes of palmitic acid analogues containing either an ether or triazolyl group at various positions along the chain. The compounds were evaluated for their ability to inhibit the formation of osteoclasts in primary mouse bone marrow cultures. The oxyacids were generally prepared by condensation of the appropriate alkyl halides and diols, followed by Jones oxidation. The triazolyl acids were prepared by copper-catalysed click chemistry between alkyl azides and acetylenic acids, or with the appropriately-protected azides and alkynes, followed by deprotection and oxidation. The oxyacids were little more effective than palmitic acid, but the triazolyl analogues were much more effective osteoclastogenesis inhibitors, especially when the triazole was distant from the acid unit.
Contrast media for infarction and necrosis imaging
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, (2008/06/13)
The invention relates to new compounds that are suitable as contrast media especially for infarction and necrosis imaging, process for their production and pharmaceutical agents that contain these compounds.
