60644-65-7

Upstream product

• 2177-70-0 phenyl methacrylate 
• 92207-37-9 3-chloro-1-(p-hydroxyphenyl)-2-methyl-1-propanone 
• 50-00-0 formaldehyd 
• 70-70-2 4-hydroxypropiophenone 
• 79-41-4 poly(methacrylic acid) 
• 108-95-2 phenol 
• 92207-32-4 3-hydroxy-1-(4'-hydroxyphenyl)-2-methylpropanone 

Downstream Products

• 92748-95-3 4-(2,6-Dimethyl-6,7-dihydro-[1,3,4]oxadiazepin-5-yl)-phenol 
• 123716-72-3 1-Acetyl-3-(4-hydroxyphenyl)-4-methyl-4,5-dihydropyrazole 

Relevant academic research and scientific papers

A methylene compound of preparation method and its application (by machine translation)

The invention discloses a methylene compound of preparation method and its application, relates to the field of organic synthesis, the process comprises: 1) in the presence of a three-valent metal salt catalyst, will arone compound and halogen methyl radical trialkyl ammonium salt dissolved in a solvent, 2) 80 - 130 °C reaction 1 - 4 hours, separated and purified α - the methyl radical is fragrant compounds, the reaction environment pollution is small, substrate and wide range of application. (by machine translation)

Thermal retro-aldol reaction using fluorous ether F-626 as a reaction medium

A high-boiling, fluorous-organic hybrid ether, F-626, was tested for use in thermal retro-aldol reactions and found to be an excellent reaction medium in view of the ease of separation from the product by fluorous/organic biphasic treatment. The recovered F-626 can be readily reused for subsequent runs.

Preparation of trifluoromethylated dihydrocoumarins, indanones, and arylpropanoic acids by tandem superacidic activation of 2-(Trifluoromethyl) acrylic acid with arenes

Chemical Reaction Reprentation Indanones and coumarins are important intermediates for the convenient synthesis of many pharmaceutical and biologically active compounds. Fluoroorganics play a vital role in the design of very effective therapeutics due to significant enhancenment in their lipophilicity, bioavailability, and fast uptake by the presence of fluorine in these molecules. Herein, we report an efficient one-pot synthesis of trifluoromethylated arylpropanoic acids, indanones, and dihydrocoumarins using Friedel-Crafts alkylation or tandem Friedel-Crafts alkylation-cycloacylation of arenes/phenols with 2-(trifluoromethyl)acrylic acid under superacidic conditions using trifluoromethanesulfonic acid. The results have been rationalized by the structure energy calculations of the involved reaction intermediates using ab initio theoretical methods.