606494-51-3

Upstream product

• 100-39-0 benzyl bromide 
• 1679-47-6 3-methyltetrahydro-2-furanone 

Downstream Products

• 1426307-42-7 C₁₉H₂₈O₃ 
• 1426307-43-8 C₁₈H₂₆O₄ 
• 1426307-44-9 C₁₈H₂₈O₄ 
• 1426307-27-8 C₁₆H₂₅NO₂ 
• 108303-99-7 (R)-1-benzyl-3-methylpyrrolidin-2-one 
• 2938-98-9 (R)-2-methylbutane-1,4-diol 
• 1426307-29-0 C₁₆H₂₄O₃ 
• 1426307-30-3 isopropyl 4-(benzyloxy)-2-methylbutanoate 
• 1426307-31-4 C₁₉H₃₀O₃ 

Relevant academic research and scientific papers

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

CYCLIC PHOSPHATE SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to Cyclic Phosphate Substituted Nucleoside Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, B, Q, V, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising a Cyclic Phosphate Substituted Nucleoside Derivative, and methods of using the Cyclic Phosphate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

Facile synthesis of versatile enantioenriched α-substituted hydroxy esters through a Bronsted acid catalyzed kinetic resolution

An efficient synthesis of enantioenriched α-substituted γ-hydroxy esters via a kinetic resolution event is described. Bulky racemic esters in the presence of a chiral Bronsted acid selectively lactonize to yield a recoverable enantioenriched hydroxy ester and lactone. These esters are highly versatile building blocks that can readily be converted to synthetically useful materials.