60656-27-1

Upstream product

• 58199-07-8 ethyl α-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-α-oxoacetate 
• 59-88-1 phenylhydrazine hydrochloride 
• 213272-97-0 N-(3,4-dihydro-1-naphthyl)acetamide 
• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 53120-34-6 ethyl 2-(1-hydroxy-3,4-dihydronaphthalen-2-yl)-2-oxoacetate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 60656-32-8 1-phenyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid 
• 665020-20-2 1-phenyl-1H-benzo[g]indazole-3-carboxylic acid 
• 665020-25-7 ethyl 1-phenyl-1H-benzo[g]indazole-3-carboxylate 

Relevant academic research and scientific papers

Cycloaddition of Nitrile Imines with Enamides: An Approach to Functionalized Pyrazolines and Pyrazoles

An efficient [3 + 2] cycloaddition of in situ generated nitrile imines with enamides has been established. A wide range of functionalized pyrazoline derivatives (53 examples) were obtained in moderate to good yields (up to 96%) under very mild conditions. This protocol features broad substrate scope, good functional group tolerance, and operational simplicity. Practical transformation of the products into useful pyrazoles via a one-pot process and the scalability of this protocol highlight the utility of this synthetic methodology.

'One-pot' synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction

A concise 'one-pot' synthesis of a variety of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2,4-diketoesters. Furthermore, extensive studies lead to a 'one-pot' process by combination of the Claisen condensation and the Knorr reaction for the synthesis of highly valuable 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates.

Chromophore-modified bis-benzo[g]indole carboxamides: Synthesis and antiproliferative activity of bis-benzo[g]indazole-3-carboxamides and related dimers

Tricyclic pyrazole dimers that comprise two kinds of CONH-(CH 2)n-N(CH3)-(CH2)n-NHCO bridges to which are linked potential DNA-intercalating groups such as 1H-benzo[g]indazole, 2H-benzo[g]indazole and

3-AMIDOPYRAZOLE DERIVATIVES, PROCESS FOR PREPARING THESE AND PHARMACEUTICAL COMPOSITES CONTAINING THEM

The present invention relates to new pyrazole derivatives possessing an amide group substituted with an amino acid or one of its derivatives at position 3 and variously substituted in positions 1, 2, 4 or 5 of the pyrazole ring, to a process for preparing these and to pharmaceutical compositions containing the said pyrazole derivatives as an active ingredient.