60660-75-5 Usage
Uses
Used in Pharmaceutical Industry:
(7S,9S)9-ACETYL-7,8,9,10-TETRAHYDRO-6,7,9,11-TETRAHYDROXY-5,12-NAPHTACENEDIONE is used as a key intermediate compound for the preparation of anthracycline disaccharides, specifically as analogs of daunorubicin. These analogs are important in the development of new drugs for the treatment of various types of cancer due to their potent antitumor properties.
In the pharmaceutical industry, (7S,9S)9-ACETYL-7,8,9,10-TETRAHYDRO-6,7,9,11-TETRAHYDROXY-5,12-NAPHTACENEDIONE plays a crucial role in the synthesis of novel anthracycline-based drugs, which can potentially offer improved efficacy, reduced side effects, and overcome drug resistance compared to existing treatments. (7S,9S)9-ACETYL-7,8,9,10-TETRAHYDRO-6,7,9,11-TETRAHYDROXY-5,12-NAPHTACENEDIONE's unique structure and functional groups allow for the development of innovative drug candidates with enhanced therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 60660-75-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,6,6 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60660-75:
(7*6)+(6*0)+(5*6)+(4*6)+(3*0)+(2*7)+(1*5)=115
115 % 10 = 5
So 60660-75-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H16O7/c1-8(21)20(27)6-11-13(12(22)7-20)19(26)15-14(18(11)25)16(23)9-4-2-3-5-10(9)17(15)24/h2-5,12,22,25-27H,6-7H2,1H3/t12-,20-/m0/s1
60660-75-5Relevant academic research and scientific papers
Stable lyophilized anthracycline glycosides
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Page/Page column 7-8, (2008/06/13)
The present invention provides lyophilized and stable lyophilized anthracycline glycoside salts, in particular, the hydrochloride salt. Also, the present invention provides methods of stabilizing these anthracycline glycoside salts, and methods for producing stable lyophilized anthracycline glycoside salts, such as for example the antineoplastic compound idarubicin hydrochloride, or the compounds doxorubicin hydrochloride, and epirubicin hydrochloride.
Total synthesis of (+)-4-demethoxydaunomycin
Ayyangar, N R,Argade, A B,Mehendale, A R,Deshpande, V H
, p. 377 - 384 (2007/10/02)
Starting from commercially available dyestuff intermediate, quinizarin (6) as BCD-ring synthon for anthracycline, a key intermediate 5b has been prepared by a simple reaction sequence. (+/-)-4-Demethoxydaunomycinone (4b) has been synthesized from 5b.Further 4b was coupled with L-daunosamine derivative (24) to give the requisite α-glycoside 4a.
