60667-24-5Relevant articles and documents
Bicyclic modulators of androgen receptor function
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, (2008/06/13)
The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
3-Aminoacetylthiazolidine-4-carboxylate Esters and their 1-Thia-4-azaspiro[4.5]decane-3-carboxylate Derivatives. Synthesis and Stereochemical Properties
Pellegrini,Refouvelet,Dachet,Rouland,Robert
, p. 1685 - 1691 (2007/10/03)
Dimethyl thiazolidine-2,4-dicarboxylate 2 and ethyl 1-thia-4-azaspiro[4.5]decane-3-carboxylates 3-5 were obtained as a diastereoisomeric mixture while their 3-aminoacetyl derivatives were isolated in only one isomeric form. These reactions of N-acylation were stereoselective, which can be explained by an interconversion of the diastereoisomers via a seco intermediate. The 1H nmr analysis of amides 6 and 11 exhibited the presence of both cis and irons amide bond conformations, whereas only one cis conformation was observed for spiro amides 8-10 and 13-15.
Tetrapeptide analog of TRH
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, (2008/06/13)
A novel tetrapeptide L-2-ketopiperidine-6-carbonyl-L-histidyl-L-thiazolidine-4-carbonyl-β-alanin-amide, (L-Kpc-L-His-L-Tca-β-ala-NH2), is a stimulant of the central nervous system. It is preparable by standard peptide synthetic procedures.
