6067-44-3

Usage

Physical state

Yellow, crystalline solid

Uses

a. Fragrance and flavoring ingredient in various products
b. Synthesis of pharmaceuticals
c. Synthesis of dyes
d. Synthesis of other organic compounds

Toxicity

Considered toxic and harmful if ingested, inhaled, or absorbed through the skin

Flammability

Flammable

Safety precautions

a. Handle with care
b. Store and handle in a well-ventilated area
c. Keep away from sources of ignition

Upstream product

• 538-93-2 1-phenyl-2-methylpropane 
• 67-64-1 acetone 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 552-89-6 2-nitro-benzaldehyde 
• 1530-33-2 isopropyltriphenylphosphonium bromide 

Downstream Products

• 91-55-4 2,3-dimethylindole 
• 22120-50-9 2,3-dimethyl-2,3-dihydro-1H-indole 
• 71182-59-7 2-isobutylaniline 
• 393078-73-4 2-methyl-1-(2-niotrophenyl)-1,2-propanediol 
• 211935-04-5 2,2,5,5-tetramethyl-4-(2-nitrophenyl)-1,3-dioxolane 

Relevant academic research and scientific papers

A cascade approach to 3D cyclic carbamates: Via an ionic decarboxylative functionalization of olefinic oxamic acids

An m-CPBA-mediated intramolecular epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. The protocol features mild reaction conditions and operational simplicity, allowing the construction of diverse medicinally valuable 5-7 membered 3D cyclic carbamate architectures in moderate to high yields.

Domino Aryne Annulation via a Nucleophilic-Ene Process

1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.

Ionic diamine rhodium complex catalyzed reductive N-heterocyclization of 2-nitrovinylarenes

Ionic diamine rhodium complex (1) catalyzes the reductive N-cyclization of 2-vinylnitroarenes using carbon monoxide as a reducing agent to afford functionalized indoles. The catalytic system allows direct access to indoles with ester and ketone groups at the 2- or 3-position, in good yields.

o-Nitroaryldioxolane for protection of pheromones. Study of the photodelivery of carbonylic compounds

o-Nitrophenyldioxolanes 1 to 12 have been prepared and the rate of their photocleavage determined Steric congestion in the molecule causes a decrease of the reaction rate. The decrease in the rate is especially important in the presence of a nitro group in a second phenyl ring.